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General cardiology
Traditional saphenous vein harvesting, so called "open harvesting", occurs under direct inspection with the aid of several linear incisions along the course of the vein. However, this technique is associated with some discomfort and also oedema, haematoma, delayed healing, cellulitis and wound dehiscence. Endoscopic vein graft harvesting was developed in an attempt to deal with some of these problems. However, to date there has been little information about the effect of this technique on long-term graft patency or on clinical outcomes.
This study was conducted through the PREVENT-IV trial (Project of Ex-vivo Vein Graft Engineering Versus Transfection). This was a phase 3 multicentre randomised, double-blind, placebo-controlled trial of ex vivo treatment of vein grafts with the E2F transcription factor decoy edifoligide, and the main results have previously been reported. The trial was conducted at 107 sites in the USA and enrolled over 3000 patients. Patients who were aged >18 years
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