Education in Heart
Stem cells in myocardial infarction: from bench to bedside
Kerckhoff Heart Center, Bad Nauheim, Germany
Correspondence to:
Dr Helge Möllmann, Kerckhoff Heart Center, Benekestrasse 2-8, 61231 Bad Nauheim, Germany; moellmann@me.com
| The first 150 words of the full text of this article appear below. |
Acute myocardial infarction (AMI) often leads to congestive heart failure, a condition associated with high subsequent mortality. Pharmacological treatment and, more importantly, primary angioplasty have notably decreased early mortality and thereby improved the long term prognosis of patients with AMI. However, in the largest study so far, involving more than 14 000 patients with AMI and impaired left ventricular function, 1 year mortality was still 13% despite guideline conforming pharmacological treatment and use of implantable automatic defibrillators.1 Therefore, preventing the progression of disease with further complications such as left ventricular aneurysm or severe depression of left ventricular function is still a major challenge.
Recent studies demonstrating the ability of stem cells to (trans-)differentiate into cardiac myocytes have challenged the old belief that the heart is a terminally differentiated organ. These findings initiated intense basic and clinical research with the aim of using this stem cell ability in order to repair
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This article has been cited by other articles:
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Hamm, C. W., Möllmann, H., Bassand, J.-P., van de Werf, F.
(2009). CHAPTER 16 Acute Coronary Syndromes. ESC Textbook of Cardiovascular Medicine
2: med-9780199566990-chapter-med-9780199566990-chapter
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