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Heart 1999;81:212-213; doi:10.1136/hrt.81.2.212
Copyright © 1999 BMJ Publishing Group Ltd & British Cardiovascular Society

Heart 1999;81:212-213 ( February )

Brief report

Disparity between studies of the stability of BNP in blood: comparison of endogenous and exogenous peptide

D R Murdoch,a J Byrne,b R Farmer,a J J Mortona

a Clinical Research Initiative in Heart Failure (Supported by The Medical Research Council), West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK, b Department of Cardiology, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK

Correspondence to: Dr Murdoch. email: drm2x@udcf.gla.ac.uk

Accepted for publication 10 August 1998

The first 150 words of the full text of this article appear below.

    Introduction

Measurement of plasma concentrations of the natriuretic peptides has recently been recognised as a potentially useful means of identifying patients with left ventricular systolic dysfunction (LVSD). Most studies, including our own,1 suggest that brain natriuretic peptide (BNP) may be superior to N-terminal atrial natriuretic peptide for diagnostic purposes. The widespread applicability of BNP would, nevertheless, be greatly diminished if the blood sample required special storage or handling. We have previously shown in a mixed population---including patients with LVSD and healthy volunteers---that endogenous BNP is stable in whole blood at room temperature for three days.2 However, other groups have published conflicting results, which at first sight cast doubt on our data3; therefore, our results have not gained universal acceptance.4-6 We, therefore, repeated our study and confirmed our original findings. Interestingly, our study is in agreement with the only other one to examine the stability of the endogenous peptide.7 . . . [Full text of this article]
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