SCIENTIFIC LETTER

Interstitial fibrosis in the dilated non-ischaemic myocardium

A Brooks, V Schinde, A C Bateman, P J Gallagher

Department of Pathology, Southampton University Hospitals, Southampton, UK

Correspondence to:
Correspondence to:
Dr P J Gallagher, Department of Pathology, Southampton University Hospitals, Southampton SO16 6YD, UK;
pjg4@soton.ac.uk

Accepted 10 March 2003

Keywords: dilated myocardium; interstitial fibrosis; collagen

The first 150 words of the full text of this article appear below.

Coronary artery occlusion and a variety of inflammatory disorders are followed by focal or segmental areas of fibrous scarring. The causes of interstitial fibrosis are less clear. Variable but sometimes dense interstitial fibrosis is seen in dilated cardiomyopathy.¹ Some reports suggest that interstitial fibrosis is also increased in non-infarcted myocardium from hearts with ischaemic scars.² Because of current interest in the pathophysiology of ventricular dilatation, we compared the interstitial collagen content of the left and right ventricles in dilated and undilated hearts of subjects without significant coronary artery occlusion. Our hypothesis was that we would find histological evidence of increased interstitial collagen content in dilated hearts.

Forty four hearts were selected from approximately 500 necropsies of adults who died in the community or at Southampton University Hospitals over a six month period. For case selection mitral valve circumference was measured. Hearts with a mitral valve circumference > 110 mm were . . . [Full text of this article]

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