Heart 2009;95:1556-1558
Editorials
Bimodal distribution of angiographic measures of restenosis: what does it mean?
1 Interventional Cardiology Unit, San Raffaele Scientific Institute, Milan, Italy
2 Division of Cardiology, Department of Medicine, University of Cape Town, Cape Town, South Africa
3 Interventional Cardiology Unit, EMO-GVM Centro Cuore Columbus, Milan, Italy
4 Department of Cardiology, St James Hospital, Dublin, Ireland
Correspondence to Dr A Latib, EMO-GVM Centro Cuore Columbus, 48 Via M. Buonarroti, 20145 Milan, Italy; info@emocolumbus.it
| The first 150 words of the full text of this article appear below. |
The study by Byrne et al1 in this edition of Heart, analysing the distribution of angiographic measures of restenosis after drug-eluting stent (DES) implantation, provides an opportunity for reflection and discussion of the applicability of surrogate end points in the evaluation of coronary stents (see page 1572). A surrogate end point is defined as a biomarker that is intended to substitute for a clinical end point and is expected to predict clinical outcomes based on epidemiological, therapeutic, pathophysiological, or other scientific evidence.2 The concept of using physical signs, laboratory assays, or imaging measures as a substitute for clinical outcomes has a long history and surrogate end points have become frequently used in all branches of medical research. In cardiology, blood pressure, cholesterol and haemoglobin A1C are all used as surrogates for clinical vascular events, including death, stroke and myocardial infarction.3 They are attractive end points in
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- Distribution of angiographic measures of restenosis after drug-eluting stent implantation
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Heart 2009 95: 1572-1578.[Abstract] [Full Text] [PDF]
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