Clinical and echocardiographic assessment of the Medtronic ADVANTAGE aortic valve prosthesis: the Scandinavian multicentre, prospective study

Rune Haaverstad ¹, Nicola Vitale ^1*, Asbjørn Karevold ¹, Giangiuseppe Cappabianca ¹, Arve Tromsdal ¹, Peter Skov Olsen ², Lars Köber ², Halfdan Ihlen ³, Kjell Arne Rein ³ and Jan L. Svennevig ³

¹ Department of Cardiothoracic Surgery, University of Trondheim, Norway
² Department of Cardiothoracic Surgery, Rigshospitalet, Copenhagen, Denmark
³ Department of Cardiothoracic Surgery, Rikshospitalet, Oslo, Norway

^* To whom correspondence should be addressed. E-mail: nicola_vitale{at}lycos.co.uk.

Accepted 19 September 2006

Abstract

Objective The aim of this report is the prospective, multicentre evaluation of clinical results and haemodynamic performance of the Medtronic ADVANTAGE aortic valve prosthesis.

Methods and Results From April 2001 to June 2003 166 patients (M:F=125:41; mean age 61.8±11.8 years) received an aortic ADVANTAGE valve prosthesis. Complete cumulative follow-up was 242.7 pt-years (maximum 3.2; mean 1.6 years). Postoperatively patients underwent early (within 30 days) and one year transthoracic echocardiography. Thirty day mortality was 2.4 % (n=4). Kaplan-Meier estimates of freedom from complications and linearized rates were as follows: survival 96.9±1.6%; thrombo-embolism 94.7±1.3% (2.06 pts/yr); bleeding 99.4±0.6% (0.4 pts/yr); non-structural valve dysfunction 98.8±0.9% (0.8 pts/yr); reoperation 98.8±0.9% (0.8 pts/yr). Valvular mean pressure gradients ranged from 16±3 mmHg for size 19 to 7±2 mmHg for size 27, and the corresponding effective orifice areas ranged from 1.2±0.25 cm2 to 3.2±0.66 cm2. Overall, left ventricular mass significantly decreased (p< 0.0001) and fractional shortening increased (p< 0.0001) from postoperative to one year echo.

Conclusions Haemodynamic performance and early clinical results of Medtronic ADVANTAGE in the aortic position were satisfactory and comparable with those of other bileaflet valves in current clinical use.

Keywords: Aortic valve surgery, Bileaflet valve, Echocardiography, Mechanical valve prosthesis, Medtronic ADVANTAGE

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Haaverstad, R., Vitale, N., Tromsdal, A., Hegbom, K., Karevold, A. (2007). Intermittent incomplete closure of Medtronic Advantage aortic valve leaflets causes unnecessary reoperation. J. Thorac. Cardiovasc. Surg. 134: 791-792 [Full Text]