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Electronic Letters to:

I Daehnert, C Rotzsch, M Wiener, and P Schneider
Rapid right ventricular pacing is an alternative to adenosine in catheter interventional procedures for congenital heart disease
Heart 2004; 90: 1047-1050 [Abstract] [Full text] [PDF]
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[Read eLetter] Risk assessment with low numbers
R A Johnson   (15 September 2004)

Risk assessment with low numbers 15 September 2004
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R A Johnson,
Doctor

Send letter to journal:
Re: Risk assessment with low numbers

johnsonra{at}doctors.org.uk R A Johnson

Dear Editor,

In their article discussing the use of right ventricular pacing in balloon dilatation of the aortic valve Daehnert et al describe the procedure as "safe". Whether a process is safe or not doeas rather depend on your point of view. However the use of the term safe applied in the context a procedure used in 14 patients is clearly not justified. The underlying risk of mortality could be as high as nearly 20% with a confidence interval of 95%. Surely no-one could describe such a level of risk as "safe".

When describing series without an adverse event doctors must remember that there is a statistical possibility that such a series may have occurred by chance and that the underlying risk is higher than it appears.