To the Editor, We have read Ghadri et al’s1 article which provides a very useful review to help us better understand Takotsubo cardiomyopathy (TTC), a sometimes puzzling disorder. In the ‘TTC TYPES’ section, the authors state that TTC often affects different LV regions in the recurrent episodes. Similar findings have been reported repetitively by other studies2 ,3 and have been found in our own patients with TTC. A consistent theme that appears to emerge is that recurrent TTC tends to change its original LV contractile pattern, to avoid significant haemodynamic compromise induced by the previous episode. This brings up an interesting question: does the heart have a mind of its own, to …