Testosterone Therapy: No Impact on Atherosclerosis…and No Improvements in Health

For men with age-related decline in testosterone levels, there is significant controversy over the risks and benefits of testosterone supplementation. Despite a paucity of data, testosterone sales have increased markedly in the past decade. The Testosterone's Effects on Atherosclerosis Progression in Aging Men (TEAAM). Trial evaluated the impact of increasing testosterone concentrations on progression of atherosclerosis as determined by common carotid artery intima-media thickness and coronary artery calcium. In addition, the investigators evaluated the effect of testosterone therapy on patient reported sexual function and health-related quality of life (SF-36). This randomized, double-blind, placebo-controlled trial enrolled 308 men >60 years old with low or low-normal testosterone (100–400 ng/dL) levels and compared testosterone supplementation …