Objective To study of the relationship between serum Angiotensin-(1–7) and cardiac remodelling in patients with congenital heart disease
Methods 90 patients with congenital heart disease and 30 normal control patients were collected, The patients with non-cardiac remodelling group are 69 cases, The patients with cardiac remodelling group are 21 cases according to echocardiogram. The serum level of Ang-(1–7) protein levels were detected by enzyme-linked immunosorbent assay (ELISA), Statistical analysis was performed by using SPSS 17.0 software. All data are presented as mean ± standard deviation and were compared using the ANOVA. A p value <0.05 was considered statistically significant.
Result The Ang-(1–7) protein levels in plasma measured by enzyme-linked immunosorbent assay were (17.39 ± 1.33) pg/ml, (21.73 ± 3.91) pg/ml, (12.52 ± 1.85) pg/ml in normal control group, congenital heart disease with non-cardiac remodelling group, congenital heart disease with cardiac remodelling group. The levels of Ang-(1–7) protein levels showed significantly difference among the three groups (p < 0.05).
Conclusions Ang-(1–7) protein levels in the patients with congenital heart disease combined with cardiac remodelling have significantly decreased.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.