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ASSA14-07-01 The study of the relationship between serum Angiotensin-(1–7) and cardiac remodelling in patients with congenital heart disease
  1. HL Dai1,2,3,
  2. YF Gong1,
  3. XF Guang1,
  4. XL Yin1
  1. 1Department of Cardiology, Yan'an Affiliated Hospital of Kunming Medical University, Yunnan Cardiovascular Hospital, Kunming, P. R. China
  2. 2Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming, P. R. China
  3. 3Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Australia

Abstract

Objective To study of the relationship between serum Angiotensin-(1–7) and cardiac remodelling in patients with congenital heart disease

Methods 90 patients with congenital heart disease and 30 normal control patients were collected, The patients with non-cardiac remodelling group are 69 cases, The patients with cardiac remodelling group are 21 cases according to echocardiogram. The serum level of Ang-(1–7) protein levels were detected by enzyme-linked immunosorbent assay (ELISA), Statistical analysis was performed by using SPSS 17.0 software. All data are presented as mean ± standard deviation and were compared using the ANOVA. A p value <0.05 was considered statistically significant.

Result The Ang-(1–7) protein levels in plasma measured by enzyme-linked immunosorbent assay were (17.39 ± 1.33) pg/ml, (21.73 ± 3.91) pg/ml, (12.52 ± 1.85) pg/ml in normal control group, congenital heart disease with non-cardiac remodelling group, congenital heart disease with cardiac remodelling group. The levels of Ang-(1–7) protein levels showed significantly difference among the three groups (p < 0.05).

Conclusions Ang-(1–7) protein levels in the patients with congenital heart disease combined with cardiac remodelling have significantly decreased.

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