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ASSA14-11-04 Role of MiR-126 in development of hypertension MiR-126:a valuable predictor for hypertension
  1. W Zhang1,
  2. Y Nan2,
  3. L Yu1,
  4. J Yang1,
  5. J Li3
  1. 1Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi’an, China
  2. 2Departments of Physiology, Xi’an Medical University, Xi’an, China
  3. 3Departments of Physiology, Fourth Military Medical University, Xi’an, China

Abstract

Objective Plasma microRNAs (miRNAs) have been recently reported to be sensitive and specific biomarkers of various tissue injuries and pathological conditions. MiR-126 plays an important role in maintaining endothelial cell homeostasis and vascular integrity. The goal of this study was to assess whether MiR-126 is good tool for the prognostication of hypertension.

Methods The plasma concentrations of miR-126and miR-499 were assessed among patients with pre-hypertension and hypertensionby a real-time reverse transcription-polymerase chain reaction using an artificial small RNA as an internal.

Results Plasma concentrations of miR-126 inpatients either with pre-hypertension (n = 22) or with hypertension (n = 36) were significantly lower than those in healthy controls (n = 15) (p < 0.01), and the concentrationsof hypertension group decreased more significantly. However, there was no difference in plasma concentrations of miR-499 among the study groups.

Conclusions Thesefindings suggest that miR-126 may be a useful biomarker for pre-hypertension and clinical hypertension.

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