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ASSA14-14-03 Clinical analysis of Down's syndrome with congenital heart diseases
  1. W Qi-Guang,
  2. Z Xian-Yang,
  3. H Xiu-Min,
  4. Z Duanzhen,
  5. C Chun-Sheng,
  6. C Huo-Yuan,
  7. G Jun-Jun,
  8. X Jia-Wang
  1. Department of Congenital Heart Disease, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning 110016, China

Abstract

Background To analyse congenital heart deformity and haemodynamic data of Down’s syndrome.

Methods We diagnosed 36 patients of congenital heart disease patients with Down syndrome by transthoracic two-dimensional echocardiography, colour Doppler flow imaging and right heart catheterization or angiocardiography from July 2008 to October 2012. This article analysed 36 cases of clinical data of Down’s syndrome with congenital heart disease and its hemodynamics.

Results Among 36 cases, including VSD 10 cases, AVSD 6 cases, PDA 6 cases, ASD 2 cases, ASD + PDA 2 cases, ASD + VSD 1 case, ASD + PDA + VSD 1 case, VSD + PDA 4 cases, PDA + BAV 1 case, TOF 2 cases, TOF + ASD 1 case in which 18 patients had pulmonary hypertension, including 5 cases of resistant pulmonary arterial hypertension.

Conclusions In cardiovascular malformations with Down syndrome, VSD (28%), AVSD (17%) and PDA (17%) are most common and were often associated with ASD or TOF. In patients absent of pulmonary artery stenosis, there were half of them combined with pulmonary artery hypertension.

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