Objective To retrospectively investigate the effectiveness and safety of ch-BNP in treatment of patients with acute left heart failure.
Methods Ninety-nine patients with acute left heart failure were studied and randomly divided into two groups: control group (n = 48) with normal treatment and ch-BNP group (n = 51) with normal treatment + ch-BNP. ch-BNP 1.5–2 mg/kg bolus, 0.0075–0.01 mg/kg/min was given intravenously everyday for 5–7 days. The heart functions of the patients were evaluated and the heart indexes, adverse effect were monitored after the seven administrations.
Results The rates of heart function improvement in the ch-BNP group were higher than that in the control group (83.4% vs 54.2%, p < 0.05). There was not significantly adverse drug reaction.
Conclusion ch-BNP in treatment of patients with acute left heart failure is effective and safe.
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