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23 Longitudinal but not circumferential strain is associated with healthy ageing: a strain-encoded cardiac magnetic resonance imaging study at 3.0TESLA
  1. Kenneth Mangion1,2,
  2. Guillaume Clerfond1,
  3. David Carrick1,2,
  4. John McClure1,
  5. Samuli M Rauhalammi1,
  6. David Corcoran1,2,
  7. Christie McComb3,
  8. Aleksandra Radjenovic1,
  9. Colin Berry1,2
  1. 1BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK
  2. 2West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK
  3. 3Clinical Physics, NHS Greater Glasgow and Clyde, Glasgow, UK


Background Displacement encoding with stimulated echoes (DENSE) encodes myocardial tissue displacement into the phase of the MRI image permitting direct quantification of myocardial displacement at multiple cardiac phases. Strain-encoded CMR with DENSE has high spatial (3.2 mm × 3.2 mm × 8 mm) and temporal resolution (TR= 27.34 ms). We aimed to measure myocardial strain values with DENSE in healthy adults across a broad age range at 3.0Tesla.

Methods Healthy volunteers with no prior medical history or treatment were enrolled and underwent CMR at 3.0T (Magnetom Verio, Siemens, Erlangen, Germany). Mid-left ventricular short axis and horizontal long axis DENSE sequences were obtained, and analysed using CIM_DENSE2D software (University of Auckland, New Zealand and Siemens Healthcare). Segmental and global myocardial circumferential (Ecc) and longitudinal (Ell) strain were obtained with DENSE.

Results 77 participants (mean (SD) age 43.0(16.9) years; range 18–78 years; 40 (52%) males;) were grouped into 3 tertiles according to age. Longitudinal strain differed according to age tertile with strain being greatest in individuals 35–55 years compared to younger or older subjects. There were no differences in Ecc according to age per tertile (Table 1).

Abstract 23 Table 1

Age differences in peak circumferential (Ecc) and peak longitudinal (Ell) strain in healthy volunteers at 3.0T

Conclusion Longitudinal myocardial strain, as revealed by strain-encoded CMR, is associated with chronological age in healthy adults.

Funding Medical Research Scotland project grant. Professor Berry was supported by a Senior Clinical Fellowship from the Scottish Funding Council.

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