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24 Peak circumferential strain assessed using strain-encoded cardiac magnetic resonance (dense) in healthy volunteers at 1.5- and 3.0 TESLA
  1. Kenneth Mangion1,2,
  2. Guillaume Clerfond1,
  3. David Carrick1,2,
  4. John McClure1,
  5. Samuli M Rauhalammi1,
  6. David Corcoran1,2,
  7. Christie McComb3,
  8. Aleksandra Radjenovic1,
  9. Colin Berry1,2
  1. 1BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK
  2. 2West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK
  3. 3Clinical Physics, NHS Greater Glasgow and Clyde, Glasgow, UK


Background Displacement Encoding with Stimulated Echoes (DENSE) is a strain-encoded cardiac magnetic resonance (CMR) method that directly quantifies left ventricular (LV) mechanics within myocardial regions. Strain values might vary according to CMR field strength. In order to assess this possibility, we implemented strain-encoded CMR at 1.5 Tesla and 3.0 Tesla with DENSE in healthy adults.

Methods Healthy volunteers without any medical history or treatment gave informed consent and underwent CMR at 1.5T (Magnetom Avanto, Siemens Healthcare) and 3.0T (Magnetom Verio; Siemens Healthcare) within 24 h. The imaging protocol included balanced steady state free precession (b-SSFP) sequences for cardiac anatomy and function and strain-encoded CMR with DENSE. (CIM_DENSE2D software (University of Auckland, New Zealand; Siemens Healthcare). Global- and segmental circumferential strain was measured at the mid-ventricular level.

Results Sixty five participants (31 (48%) male, mean age 44 ± 18) were included (Table 1). Mean global and regional strain values differed slightly between 1.5T and 3.0T, and these differences were mainly related to strain values in the anterior and anterolateral LV segments were LV displacement is greatest.

Conclusion Strain-encoded CMR with DENSE provides regionally localised measurements of circumferential strain. Subtle field-strength differences were apparent for anterior/antero-lateral LV strain.

Funding Medical Research Scotland project grant. Professor Berry was supported by a Senior Clinical Fellowship from the Scottish Funding Council.

Abstract 24 Table 1

Global Circumferential Strain in 65 Healthy Volunteers

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