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27 Regional variations in myocardial T1 relaxation times in healthy adults at 1.5 and 3.0 TESLA
  1. S Rauhalammi1,
  2. D Carrick1,2,
  3. K Mangion1,
  4. G Clerfond1,
  5. P Hall Barrientos1,
  6. C McComb1,
  7. A Radjenovic1,
  8. C Berry1,2
  1. 1BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK
  2. 2Golden Jubilee National Hospital, UK

Abstract

Background Limited information is available on regional differences in myocardial T1 relaxation times in healthy adults. We used cardiac magnetic resonance (CMR) imaging at two field strengths, 1.5- and 3.0 Tesla (T), to assess regional distribution of T1, in milliseconds (ms), in myocardial regions-of-interest (ROIs) in healthy adults.

Methods Healthy adults without history of cardiovascular disease underwent CMR at 1.5 T (Avanto) and 3.0 T (Verio). T1 maps were acquired in three left ventricular (LV) short-axis slices, using an optimised modified Look-Locker inversion recovery (MOLLI) investigational prototype sequence (Siemens WIP 448). ROIs were delineated using the American Heart Association 16-segment model.

Results 80 consecutive volunteers (41 (51.3%) male, mean age 44 ± 18 years) underwent scans 1.5 ± 1.4 days apart. Because of artefacts related to cardio-respiratory motion and susceptibility effects, 44 (3.4%) segments imaged at 1.5 T and 71 (5.5%) at 3.0 T were excluded, respectively, with a preponderance occurring at the distal LV. Mean T1 values at 1.5 T/3.0 T were 946.5 ± 50.3 ms/1152.0 ± 54.9 ms. At 1.5 T there were regional differences across 16 segments (Table 1); T1 values from myocardial septal ROIs (956.7 ± 44.8 ms) were higher than non-septal ROIs (941.8 ± 52.0 ms, p < 0.001). T1 was lower in lateral ROIs (939.7 ± 54.1 ms) vs. non-lateral ROI (949.6 ± 48.1 ms, p < 0.005). The regional differences were similar at 3.0 T (Table 1).

Abstract 27 Table 1

Segmental myocardial T1 times (mean ± SD, ms)

Conclusion T1 values vary according to myocardial location. The explanation may be related to myocardial structure/function relationships and merits further study.

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