Background Displacement encoding with stimulated echoes (DENSE) encodes myocardial tissue displacement into the phase of the MRI image, thus allowing direct quantification of myocardial displacement at multiple cardiac phases. Strain-encoded CMR with DENSE has high spatial (3.2 × 3.2 × 8 mm) and temporal resolution (32.5 ms phase). We aimed to measure myocardial strain values with DENSE in healthy adults across a broad age range at 1.5 Tesla.
Methods Healthy volunteers with no prior medical history (including cardiovascular health problems or medication) were enrolled and underwent CMR at 1.5T (Magnetom Avanto, Siemens Healthcare, Erlangen, Germany). Mid-left ventricular short axis and horizontal long axis DENSE sequences were obtained, and analysed using CIM_DENSE2D software (University of Auckland, New Zealand and Siemens Healthcare). Segmental and global myocardial circumferential and longitudinal strain were obtained.
Results LV dimensions and circumferential strain were available for 75 volunteers (mean age 44.12 ± 17.7 years old, 48% male) (Table 1). Longitudinal strain was acquired in a subset of participants (n = 20). Mean global circumferential (Ecc) and longitudinal (Ell) strain were greater in women than in men. These differences were mainly related to strain values in the inferior, infero-lateral and antero-lateral LV segments for the circumferential strain and the apico-lateral segment for the longitudinal strain where LV displacement is greatest.
Conclusion Strain-encoded CMR with DENSE has revealed sex differences in myocardial contractility in healthy adults.
Funding Medical Research Scotland project grant. Professor Berry was supported by a Senior Clinical Fellowship from the Scottish Funding Council.
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