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42 Myocardial Lipid Accumulation and Cardiac Remodelling in Heart Failure with Reduced and Preserved Ejection Fraction
  1. Masliza Mahmod1,
  2. Nikhil Pal2,
  3. Cameron Holloway2,
  4. Vanessa Ferreira2,
  5. Sairia Dass2,
  6. Jane Francis2,
  7. Oliver Rider2,
  8. Theodoros Karamitsos2,
  9. Houman Ashrafian2,
  10. Stefan Neubauer2
  1. 1OCMR, University of Oxford
  2. 2University of Oxford

Abstract

Introduction Heart failure (HF) is characterised by alterations in myocardial metabolism with a compensatory shift from fatty acid to glucose metabolism. This could potentially lead to myocardial lipid accumulation (steatosis). We aimed to determine if myocardial lipid is increased in HF with reduced (HFrEF) and preserved (HFpEF) ejection fraction (EF), and assess whether it is related to cardiac structure and function.

Methods 71 subjects (25 HFrEF due to dilated cardiomyopathy-DCM, 18 HFpEF and 28 normal volunteers were prospectively recruited). HFpEF was defined by left ventricular (LV) ejection fraction (EF) >50%, abnormal diastolic function, maximum oxygen consumption < 80% predicted for age, height and gender, with a cardiac limitation in exercise. All subjects underwent cardiovascular magnetic (MR) resonance at 3T for the determination of LV volumes and function and 1H-MR spectroscopy (MRS) to quantify myocardial lipid/water (%).

Results All subjects were matched for gender, body mass index, blood glucose, free fatty acids and lipid profile. As expected HFrEF patients had significantly increased LV volumes and reduced EF, whilst HFpEF patients had significantly increased LV mass to end-diastolic volume ratio (LV mass/EDV). Importantly, cardiac lipid was increased in both HFrEF and HFpEF when compared to normal controls (cardiac lipid/water 0.67 ± 0.42% in HFrEF; 1.06 ± 0.83% in HFpEF vs. normal controls 0.44 ± 0.17, all p < 0.05), with HFpEF having the highest level of cardiac lipid (Table 1, Figure 1). In HFrEF patients, cardiac lipid negatively correlated with LVEF and positively correlated with LV size. In HFpEF, cardiac lipid positively correlated with age and LV mass/EDV. Although HFpEF patients were significantly older, multiple regression analysis showed that age was not an independent predictor of cardiac lipid.

Abstract 42 Table 1

Characteristics of patients with reduced (HFrEF), preserved (HFpEF) ejection fraction and normal volunteers

Abstract 42 Figure 1

Cardiac lipid content in HFrEF, HFpEF and normal subjects. *p < 0.05 vs HFpEF and normal; **p < 0.05 vs normal

Conclusions Myocardial steatosis occurs in both HFrEF and HFpEF and is related to parameters of LV remodelling. This suggests that myocardial lipid may play a role in the pathophysiological processes of LV remodelling in both HFrEF and HFpEF. Cardiac lipid accumulation may be a potential therapeutic target in these conditions.

  • Steatosis
  • Heart failure with reduced ejection fraction
  • Heart failure with preserved ejection fraction

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