Background Systemic sclerosis (SSc) is a chronic disease characterised by systemic inflammation, vasculopathy and fibrosis. Primary myocardial disease occurs in both limited (lcSSc) and diffuse (dcSSc) cutaneous subtypes, and carries a poor prognosis. The natural history is poorly understood, with no clear approach to identifying the ‘at-risk’ patient. CMR studies in SSc have rarely correlated with disease phenotype.
Objectives To determine cardiovascular manifestations of SSc using multi-component CMR.
Method Eleven patients fulfilling SSc ACR/Le-Roy criteria, without known CV disease or diabetes, underwent CMR at 3.0T (Philips Achieva TX). Data from 10 healthy subjects served as a control group. Standard bSSFP cine images were acquired and LV dimensions calculated. First-pass perfusion imaging in three short-axis LV slices was performed during administration of 0.1 mmol/kg of gadobutrol at 3 min of 140 mcg/kg/min adenosine for stress and repeated 15 min later at rest. Myocardial perfusion reserve (MPR) was calculated using Fermi deconvolution (PMI v.0.4, [Sourbron, 2009] with basal blood pool providing the arterial input. Native and 15 min post final contrast T1 maps were generated from mid-LV short axis using a modified 3,3,5 Look-Locker inversion sequence to calculate extra-cellular volume (ECV) fraction.
Results Patient characteristics were as follows: Mean age 54 ± 16, disease duration 9.6 ± 7.3 years, 7 female, 7 lcSSc subtype, 4 dcSSc subtype, 5 interstitial lung disease. Smoking status: 1 current, 8 ex-smoker, 2 never. 3 have known hypertension. CMR measurements are presented in Table 1.
One patient with lsSSc subtype showed lateral mid-ventricular wall enhancement on LGE. ECV increased and MPR decreased with age (r = 0.657, p = 0.039; rho= -0.75, p = 0.02 respectively). A non-significant trend for a higher ECV was noted in lcSSc subtype (mean ECV 33% vs. 28% dcSSc subtype, p = 0.14). ECV was similar for disease duration (mean ECV 33% >10 years vs. 30% <10 years, p = 0.2). MPR was non-significantly lower in lcSSc subtype (mean 1.83 vs. 2.13 in dcSSc subtype, p = 0.3) and there was no strong association with disease duration. MPR in SSc was lower than in healthy controls (n = 9) (1.9 vs. 2.8, p = 0.03).
- Systemic Sclerosis
- Cardiac MRI
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.