Article Text

PDF
113 Neointimal Coverage of Bioresorbable Vascular Scaffolds within Four Months – Can we Stop Dual Antiplatelets Early?
  1. Joel Giblett1,
  2. Adam Brown1,
  3. Harry Keevil2,
  4. Nick West1,
  5. Stephen Hoole1
  1. 1Papworth Hospital
  2. 2University of Cambridge

Abstract

Background Neointimal strut coverage significantly reduces risk of stent thrombosis, which may allow abbreviated dual anti-platelet therapy if clinically necessary. Optical coherence tomography (OCT) provides unparalleled axial resolution to define strut coverage. We used OCT to assess neointimal strut coverage of Bioresorbable Vascular Scaffolds (BVS) at an earlier timepoint than published studies.

Methods OCT imaging was performed at baseline and 1–4 months post-implantation in patients receiving BVS. OCT scaffold strut coverage (strut thickness >160 μm), mean flow/scaffold area (MFA/MSA) and incomplete strut apposition (ISA) were assessed every 1 mm (n = 865 frames) longitudinally throughout the scaffold. Measures were compared at baseline and follow up.

Results 20 BVS (median 3.0 × 18 mm) were included in the analysis. 90% of patients were male and mean age was 54.4 ± 9.2 yrs. Median follow up was 70 (range 29–112) days. 16 (80%) stented lesions were classified as AHA B2 or C. At follow-up, only 91/3,280 struts (2.8%) were uncovered. ISA was observed for 60 struts (2.0%) at baseline and 14 struts (0.5%) at follow up (p < 0.05). Only 4 BVS (20%) had ISA at follow-up. MFA reduced from 7.79 mm2 at baseline to 7.37 mm2, at follow up (Δ-5.43%, p < 0.05), due to neointimal growth (mean area +1.07 mm2). MSA was not significantly different at follow up (-0.11 mm2, Δ-1.27%, p = 0.45).

Abstract 113 Figure 1

Image A is an OCT section through a BVS implanted coronary artery at baseline whilst image B demonstrates the same vessel at 51 days follow up with neointimal growth around the BVS struts

Conclusions BVS exhibited low rates of uncovered struts within four months following implantation. Although MFA had reduced due to neointimal growth, MSA was preserved, implying adequate BVS radial strength despite the complex lesion subset. These data suggest that abbreviated dual-antiplatelet therapy may be possible following BVS implantation if clinically necessary.

  • Bioresobable Vascular Scaffolds
  • Optical Coherence Tomography
  • Percutaneous Coronary Intervention

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.