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Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies
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Other responses

  • Published on:
    Does loneliness and social isolation really increase the risk of CHD and stroke? Pooled results based on quality effect model
    • Chang Xu, PhD candidate
    • Other Contributors:
      • Zhang Chao

    Dear editor,

    Loneliness and social isolation may lead to CHD and stroke? Valtorta et al. answered this question in a recent meta-analysis [1]. After pooling evidence based on 16 cohorts, they found that poor social relationships increase the risk of CHD and stroke. However, do things really like this? Maybe not. The problem is the random-effect (RE) model they used, which may lead to overconfident and biased re...

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    Conflict of Interest:
    None declared.
  • Published on:
    Loneliness and social isolation and increased risk of of coronary heart disease and stroke: clinical implications

    The recent meta-analysis published in Heart by Valtorta et al. (1) showed that loneliness and social isolation are associated with increased coronary heart disease and stroke incidence in 16 large longitudinal studies conducted in high income countries. This finding is not surprising given the extensive literature documenting such harmful consequences of social isolation, including a study my research group published i...

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    Conflict of Interest:
    None declared.