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217 Differences in Blood Biomarker Composition Between Paroxysmal AF and Sinus Rhythm Patients, Without Heart Failure
  1. Samantha Tull1,
  2. Elton Dudink2,
  3. Bob Weijs3,
  4. Syeeda Nashitha Kabir4,
  5. Larissa Fabritz4,
  6. Harry J Crijns5,
  7. Paulus Kirchhof4
  1. 1University of Birmingham
  2. 2MUMC, Department of Cardiology
  3. 3Maastricht University Medical Center
  4. 4Institute of Cardiovascular Sciences, University of Birmingham
  5. 5Maastricht University Medical Center Department of Cardiology, Cardiovascular Research Institute

Abstract

Introduction Atrial fibrillation (AF) affects 2% of the population and is associated with cardiovascular disease and increased stroke and mortality rates. The myocardium releases proteins (SCF, VEGF-D and BNPs). Detection of such markers in blood could be used to differentiate specific types of AF, or to guide screening for silent, undiagnosed AF.

Aim To identify plasma proteins discerning between patients with and without AF.

Methods We studied blood from consecutive patients undergoing CT coronary angiography at Maastricht Medical center. We only enrolled patients without a history of stroke, hypertension, diabetes or heart failure. Using unique DNA-coupled paired antibodies and qPCR, we simultaneously analysed 92 plasma proteins. CCL21 protein was measured by ELISA (n = 240). Stats: Mann-Whitney test, mean normalized protein expression (NPX) +/-SEM.

Results 176 patients (paroxysmal AF=50, sinus rhythm (SR) controls=126) were analysed. Mean age was 54 years in both groups. N— terminal fragment proB-type natriuretic peptide (NT-proBNP) protein was higher in patients with than in those without AF (6.23 ± 0.62 vs 4.72 ± 0.33, p = 0.012, n = 176). We also performed an exploratory analysis only in patients without signs of coronary artery disease on CTCA (AF=27, SR=80). In this subgroup, NT-proBNP (6.478 ± 0.8442 vs 4.554 ± 0.4122, p = 0.023*), BNP (1.111 ± 0.083 vs 0.9713 ± 0.029, p = 0.0175*), Stem Cell Factor (SCF, 162.8 ± 7.860 vs 140.4 ± 5.127 p = 0.0097**) and VEGF-D (47.44 ± 2.708 vs 41.38 ± 1.694 p = 0.0389*) were higher in the 27 patients with AF.

Conclusion While NT-proBNP is mostly known as a marker for heart failure, NT-proBNP appears as a potential blood marker for AF in patients without history of stroke, hypertension, diabetes or heart failure. Further validation of these initial, hypothesis-generating results seems warranted.

Abstract 217 Figure 1

Plasma NT-pro-BNP

  • AF
  • NT-proBNP
  • Biomarkers

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