Article Text


Heartbeat: Healthcare approaches to reducing adverse outcomes in patients with atrial fibrillation
  1. Catherine M Otto
  1. Correspondence to Professor Catherine M Otto, Division of Cardiology, University of Washington, Seattle, Washington, USA; cmotto{at}

Statistics from

Atrial fibrillation (AF) affects over 30 million people worldwide. The increased risk of stroke and mortality associated with AF accounts for an increasing global burden of disease, both in terms of adverse outcomes and resultant costs. In standard medical practice, adherence to guideline based preventative anticoagulation is suboptimal. An integrated care model, using a multidisciplinary team and community support to provide patient-centred care, has been proposed to improve outcomes in the AF population. In a systematic review and meta-analysis that included 1383 AF patients, Gallagher and colleagues1 found that an integrated care approach was associated with a reduction in both all-cause mortality (OR 0.51, 95%  CI 0.32 to 0.80, p=0.003) and cardiovascular hospitalisations (OR 0.58, 95%  CI 0.44 to 0.77, p=0.0002) (figure 1). However, there was no difference between integrated and standard care for endpoints of AF-related hospitalisations or cerebrovascular events.

Figure 1

Impact of integrated care on all-cause mortality. M-H, Mantel-Haenszel method.

In an editorial, Stewart2 stresses the contribution of AF to the epidemiology of cardiovascular disease given that the “population prevalence ranges from 2.3%–3.4% with a marked gradient in cases according to age. It is on this basis that 10%–20% of individuals aged >65 years develop AF with a lifetime risk of one in four.” He also points out that despite the theoretical benefits of an integrated care approach for AF patients, there is little objective data to support its widespread application at this time (figure 2). He concludes: “To bring ‘order’ to this chaotic rhythm disorder via integrated management, therefore, there is still much to be done; particularly in respect to cost-effectively dealing with what is likely to be an increasingly older and more clinically complex patient population in whom the margin of error (in terms of benefits vs risk) is likely to become narrower.”

Figure 2

Impact of AF on 30-day outcomes when combined with other common comorbid conditions in patients hospitalised with HF.  AF, atrial fibrillation; HF, heart failure.

Also in this issue, Wong and colleagues3 examined data from almost 40 000 women, with a mean age at baseline of 50 years, to study whether menopause is associated with an increased incidence of AF. Based on 1350 AF events over 20.5 years of follow-up, oestrogen-only hormone replacement therapy was associated with an increased risk of AF (HR 1.22; 95%  CI 1.02 to 1.45) but there were no significant differences based on age at menopause or use of combined hormone therapy.

In the accompanying editorial, Guhl and Magnani4 remind us that, despite this encouraging study in terms of AF risk, “Menopausal age is established as a strong marker of adverse cardiovascular risk. Earlier age of menopause has been related to increased myocardial infarction, stroke, heart failure and cardiovascular mortality” (figure 3).

Figure 3

The figure presents a hypothesised association between age of menopause and cardiovascular outcomes, emphasising the consistent absence of a relation to atrial fibrillation as borne out by multiple epidemiological studies.

The role of revascularisation versus medical therapy for older adults with non-ST-elevation acute coronary syndrome (NSTEACS) remains controversial. In a meta-analysis of four randomised trials and three observational studies that included over 20 000 patients aged 75 years or older, Gnanenthiran and colleagues5 found that a routine invasive strategy reduced the risk of death (OR 0.67, CI 0.61 to 0.74), myocardial infarction (OR 0.56, CI 0.45 to 0.70) and stroke (OR 0.53, CI 0.30 to 0.95) but resulted in a greater than twofold increased risk of major bleeding (figure 4).

Figure 4

Mortality after NSTEACS in adults aged 75 years and older, comparing a routine invasive approach with medical therapy.

De Carlo and Liga6 comment that “While adequately-powered randomised controlled trials are still needed to define the most appropriate approach in elderly patients with NSTEACS, the meta-analysis by Gnanenthiran et al 5 provides new, good-quality evidence supporting an early invasive strategy, which was associated with a significant reduction in most clinical hard endpoints. In this context, strategies able to limit the occurrence of bleeding complications (ie, trans-radial approach) and to better guide revascularisation (ie, invasive assessment of coronary flow reserve in the case of multivessel disease) should be implemented to maximise the clinical benefit and contain the risks of a routine invasive approach.”

A set of two review articles in this issue discuss the vexing problem of prosthetic valve thrombosis, both with surgically implanted bioprosthetic and mechanical valves7 and with transcatheter bioprosthetic valves8 (figure 5). These summaries of the current literature can help guide future clinical research on this important complication of heart valve replacement.

Figure 5

(A) Bileaflet mechanical mitral valve replacement. During diastole, only one leaflet opens. (B) Central jet of pathological regurgitation (arrow). (C) Increased transmitral gradient 16 mm Hg. (D) Three-dimensional view of mitral valve from atrial side. One orifice is fixed and occluded (arrow). (E) Absence of colour Doppler through occluded orifice. (F) CT demonstrating 1 cm thrombus partially occluding leaflet (arrow).

The Education in Heart article9 in this issue discusses cardiac resynchronisation therapy for management of heart failure with reduced ejection fraction. The pathophysiologic rationale, patient selection, and procedural technique are summarised concisely in this article. The Image Challenge10 shows an apical cyst on echocardiography and chest CT in a 76-year-old woman with anaemia. See if you can make the diagnosis from these images!


View Abstract


  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.