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In patients with acute heart failure (AHF), renal dysfunction is common and associated with a poor prognosis. Although both serum creatinine and blood urea nitrogen (BUN) are markers for renal dysfunction, BUN levels are also affected by reabsorption in the renal tubules, a process modulated by renin-angiotensin-aldosterone activity, sympathetic nervous activity and arginine-vasopressin activity. Thus, neurohormonal activity is reflected in the BUN/creatinine ratio which effectively ‘normalizes’ BUN for the degree of renal dysfunction, as measured by the creatinine level. To investigate the prognostic value of the BUN/creatinine ratio in AHF, Matsue and colleagues1 first defined age and sex specific normal ranges. Even in normal individuals, there is wide variation in the BUN/creatinine ratio, an increase with age, and higher levels in women compared to men. Then, in a cohort of about 2000 AHF patients, they showed that the BUN/creatinine ratio was elevated in about 25% and was a predictor of all cause death at 180 days (HR: 1.86, 95% CI 1.29 to 2.66) and of death or cardiovascular or renal rehospitalisation at 60 days (HR: 1.37, 95% CI 1.03 to 1.82) after adjustment for other variables, including creatinine and BUN. Figure 1
In the accompanying editorial (heartjnl-2016-310536), Núñez concludes: ‘Despite the encouraging results presented by Matsue et al, further studies are needed to confirm the normal/abnormal threshold for defining high/normal values of this ratio especially in older subjects, to define the clinical utility role of trajectories of BUN/Creatinine over a single measurement, and to evaluate the prognostic utility in other subgroups of patients—underrepresented in this study—such as the elderly and patients with HF with preserved ejection fraction.’
The hemodynamic changes with exercise in patients with pulmonary arterial hypertension provide important prognostic information and may be a target for therapeutic intervention, yet are incompletely understood. In an elegant and detailed study of 26 subjects with PAH, Bellofiore and colleagues2 measured proximal and distal pulmonary artery stiffness, pulmonary impedance and other measures of ventricular-vascular coupling at rest and with exercise. Compared to normal subjects, PAH patients had increased pulmonary arterial stiffness at rest and a further increase in stiffness with exercise, despite no change in pulmonary vascular resistance (the more conventional measure). Increased pulmonary stiffness was associated with inefficient right ventricular to pulmonary artery coupling. PAH patients with more efficient hemodynamic coupling at rest, had greater pulmonary vascular reserve, allowing a higher cardiac output with exercise.
Claessen and La Gerche3 put these findings in perspective with a concise summary of normal and abnormal exercise hemodynamics. Figure 3 They comment: ‘Interestingly, it was found that coupling efficiency between the RV and the pulmonary circulation at rest was associated with maximum exercise tolerance whereas conventional metrics obtained by right heart catheterisation, such as pulmonary vascular resistance or cardiac output, were not. This underscores that in order to gain insights into the determinants of exercise tolerance we should not only assess the pulmonary vasculature, but also include its interaction with the right ventricle.’
The role of percutaneous intervention (PCI) versus coronary artery bypass grafting (CABG) surgery in patients with multi-vessel coronary disease involving the proximal left anterior descending coronary artery remains controversial. In a pooled analysis of individual patient level data from the SYNTAX and BEST randomized trials, Cavalcante and colleagues4 found the primary composite outcome of all-cause death, myocardial infarction or stroke occurred in 16.3% of the PCI group and 11.5% of the CABG group at 5 years (HR 1.43; 95% CI 1.05 to 1.95; p=0.026), although all-cause death alone was not significantly different between the 2 groups. The authors suggest that ‘Due to the sample size and randomised nature of the data, this study represents the most robust available data on this specific patient subset. Its results might impact practice guidelines to recommend CABG over PCI in patients with multi-vessel coronary disease and proximal LAD involvement.’ Readers should send their comments about this recommendation to the authors using the online ‘submit a response’ option.
Also in this issue is an excellent review article entitled: ‘Development of the atrial septum in relation to anatomy and interatrial communications’5 by Professor
Anderson and colleagues which detailed evidence to correct some of the coomon clinical misconceptions about atrial anatomy. Figure 3 The Education in Heart article6 by D’Silva and Sharma discusses management of young competitive athletes with cardiovascular conditions which clinicians will find helpful in daily practice.
The Image Challenge article in this issue (heartjnl-2016-310278) shows an excellent example of the use of coronary computed tomographic angiography for diagnosis in a young patient presenting with atypical chest pain.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.
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