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008 Demonstration of cardiac AL amyloidosis regression after succesful chemotherapy. a CMR study
  1. Ana Martinez-Naharro1,
  2. Amna Abdel-Gadir2,3,
  3. Thomas A Treibel2,3,
  4. Giulia Zumbo1,
  5. Daniel S Knight1,
  6. Stefania Rosmini1,3,
  7. RN Thirusha Lane1,
  8. Shameem Mahmood1,
  9. Sajitha Sachchithanantham1,
  10. Carol J Whelan1,
  11. Helen J Lachmann1,
  12. Ashutosh D Wechalekar1,
  13. Peter Kellman4,
  14. Julian D Gillmore4,
  15. James C Moon2,3,
  16. Philip N Hawkins1,
  17. Marianna Fontana1
  1. 1National Amyloidosis Centre, University College London, Royal Free Hospital, London, UK
  2. 2Institute of Cardiovascular Science, University College London, London, UK
  3. 3Barts Heart Centre, West Smithfield, London, UK
  4. 4National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA

Abstract

Background Cardiac involvement in immunoglobulin light chain (AL) amyloidosis is the major determinant of survival; Cardiac response to chemotherapy is conventionally assessed by serum brain natriuretic peptide (NT-proBNP) and echocardiography, but neither quantify amyloid burden. The aim of this study was to evaluate cardiac AL amyloid serially using cardiovascular MR (CMR) including extracellular volume measurement (ECV), which is the site of the amyloid deposits.

Methods 31 patients with cardiac AL amyloidosis who had chemotherapy were studied serially using ECG, echocardiography, 123I-labelled serum amyloid P component (SAP) scintigraphy, NT-proBNP measurements and CMR with T1 mapping and ECV measurements (mean interval 20±11 months). Nineteen patients achieved a complete or very good partial haematological response (CR n=10; VGPR n=9). Twelve patients attained a partial response (PR) or no response (NR).

Results At follow-up (mean 20±11 months), the amyloid burden had decreased substantially in 6 of the 10 (60%) attaining a CR, 6 of the 9 (67%) in VGPR and 1 of the 8 (13%) in PR. Changes in the ECV consistent with regression of amyloid were concordant with the changes in native T1, reduction in amyloid volume and in 5 patients with changes in late gadolinium enhancement pattern (figure 1). Overall there was significant reduction in NT-proBNP concentration, LV mass, left atrial area and improvement in diastolic function in patients whose amyloid burden decreased. Regression of cardiac amyloid by CMR correlated with regression of amyloid in other organs measured by SAP scintigraphy.

Abstract 008 Figure 1

Top: four chamber SSFP cine images in disatole, corresponding late gadalinium anhancement (LGE) images and ECV mapping before and after chemotherapy in a patient who had regression of amyloid burden after chemotherapy. Bottom: four chamber SSFP cine images in disatole, corresponding LGE images and ECV mapping before and after chemotherapy in a patient who had progression of amyloid burden after chemotherapy.

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