A series of 45 patients who had a myocardial infarction before the age of 45 years has been studied and investigated for alterations of glucose tolerance, as shown by standard and prednisolone-primed glucose tolerance tests.
Abnormal responses to standard glucose tolerance tests and prednisolone-primed glucose tolerance tests were obtained in 75·5 per cent of patients with myocardial infarction, compared with 8·8 per cent of controls.
Sex, hypertension, obesity, and a positive family history did not affect the abnormalities of glucose tolerance.
Various views concerning these abnormalities in glucose metabolism are discussed.
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