Article Text

PDF

Localization of lesion in patients with idiopathic orthostatic hypotension.
  1. M M Ibrahim

    Abstract

    The different components of the baroreceptor reflex were studied in 8 patients with idiopathic orthostatic hypotension. The reflex arc was interrupted in all patients and the lesion was most probably localized to the efferent sympathetic fibres. This was suggested by the negative cold pressor test, the absence of pressor response to mental arithmetic, and loss or reflex sweating. Selective sparing of sympathetic vasodilator fibres was probable in 2 patients. Cardiac acceleration after atropine was less than in normal subjects suggesting some degree of cardiac denervation. The present study indicates that lesions in efferent sympathetic fibres are a common cause of idiopathic orthostatic hypotension. Other components of the reflex arc were intact in this series of patients.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.