Article Text


Echocardiographic evaluation of propranolol therapy for mitral valve prolapse
  1. Roger A. Winkle,
  2. Daniel J. Goodman,
  3. Richard L. Popp
  1. From Cardiology Division, Stanford University School of Medicine, Stanford, California, U.S.A.


    This study evaluates the effect of propranolol on the echocardiogram of 8 patients with late systolic mitral valve prolapse. Echocardiograms were performed with the patients on no medication and again while on oral propranolol therapy. Propranolol caused a statistically significant increase in left ventricular volume; however, neither the echocardiographic pattern nor the timing of mitral valve prolapse was altered by propranolol. These findings suggest that factors in addition to left ventricular volume play a role in regulating valvular dysfunction in this condition.

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    • 1 This work was supported in part by NIH grants.

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