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Lack of association between haemostatic variables and the presence or the extent of coronary atherosclerosis.
  1. U Schmitz-Huebner,
  2. S G Thompson,
  3. L Balleisen,
  4. C Fechtrup,
  5. W Grosse-Heitmeyer,
  6. B Kirchhof,
  7. E Most,
  8. U S Müller,
  9. C Seiffert,
  10. D Seiffert
  1. Department of Internal Medicine, University of Münster, Federal Republic of Germany.

    Abstract

    Blood samples were taken for haemostatic analysis from 225 patients with angina pectoris who were admitted to hospital for coronary angiography. beta thromboglobulin, platelet factor 3, platelet factor 4, factor VII:C, factor VIII:C, von Willebrand factor antigen, activated partial thromboplastin time, fibrinogen, antithrombin III, protein C:Ag, plasminogen, and antiplasmin were measured before angiography. Patients who had had a myocardial infarction in the two months before the investigation were excluded from the study. Multiple linear regression analysis showed that none of the haemostatic variables contributed independently to the prediction of an angiographic score that indicated the extent of coronary atherosclerosis. History of myocardial infarction, male sex, worsening of angina pectoris, serum triglycerides, and ejection fraction were independently associated with the angiographic score. There were some significant correlations between haemostatic variables and conventional risk factors for coronary heart disease. Thus data obtained from haemostatic analyses of peripheral venous blood do not permit the presence or the extent of atherosclerosis in coronary arteries to be predicted.

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