Objective To determine the status of patients 10 years after referral for coronary artery bypass graft (CABG) surgery.
Design Retrospective analysis of case notes from all patients referred between 1 April 1981 and 31 March 1985. Full information gathered from hospital notes, GP records, and Registrar General for Scotland.
Setting District General Hospital, West Lothian, Scotland.
Patients 102 patients referred for CABG during study period. Cardiac surgery was undertaken in Brompton Hospital, London, Royal Infirmary, Edinburgh, and Western Infirmary, Glasgow.
Results At 10 years after operation 32 patients had died (27 cardiac, five non-cardiac causes). Full data were not available for five patients. Of the 65 remaining patients 24 had no angina, 13 had had a repeat procedure (CABG or angioplasty), and 28 had angina.
Conclusions Long term benefits of CABG surgery is disappointing. Further steps are required to reduce progression of disease in this population.
- coronary artery bypass surgery
- repeat procedure
Statistics from Altmetric.com
Although coronary artery bypass graft (CABG) surgery has been accepted treatment for angina pectoris for 25 years few assessments of long term benefit have been available. Evidence from trials1 suggested improved survival in triple vessel and left main disease. How such trials relate to normal practice is uncertain. Hence this audit looked at experience of a single cardiologist in a district general hospital, referring to several surgical centres.
Records of all patients referred for CABG from a district general hospital in West Lothian between 1 April 1981 and 31 March 1985 were retrieved. The following information was collected; sex, age at operation, preoperative angina severity score (according to the Canadian Cardiovascular Society classification), exercise tolerance test results, angiography details including left ventricular function, and preoperative cholesterol concentrations. The details of the operation were also obtained. Outcome of the operation was obtained from the medical notes, Registrar General for deaths, and correspondence with general practitioners/other colleagues. Outcome measures used were; cardiac/non-cardiac deaths, repeat revascularisation procedure, and present anginal status including number of anti-anginal medications.
Statistical methods used were estimations of the difference between the means stated.
All the notes of the 102 patients were retrieved, but up to date information on five patients could not be obtained. Therefore 97 patients were included in this report. Eighty seven patients were male and 10 were female. The youngest age at time of operation was 29 years and the oldest was 68 years. One patient who later died of myeloma was operated on as an emergency and did not have angiography.
The results in tables 1 and 2 show the preoperative angiographic details and how they relate to exercise tolerance tests and angina severity. It was found that 43 of the 97 patients did not receive an exercise tolerance test, this included all 10 female patients. The number of patients who had their cholesterol values checked preoperatively was 14 (14%).
Four of eight single grafts done were left internal mammary arteries. One operation included an aneurysmectomy.
To date 43 patients have died (40 male and three female). Thirty six of the 43 deaths were cardiac related. The other seven died of stroke (3), renal cell carcinoma (2), myeloma (1), and metastatic carcinoma (1). Eleven patients died in the 11th and 12th year of follow up (nine cardiac deaths). These patients will be regarded as survivors for the purposes of outcome at 10 years. Figure 1 shows the survival curve.
Tables 3-5 outline the age, exercise tolerance test scores, angiographic details, and operation undergone of the 65 surviving patients as well as those who died a cardiac death.
The outcome of the 65 survivors was that 24 of them had no angina, 13 had a repeat procedure performed (either angioplasty or repeat surgery), and 28 had angina. Table 6 shows the number of years after the operation when patients experienced angina. Figure 2 shows the percentage of survivors free from angina when the year of symptom return is known. Twenty one of 28 survivors with angina were taking at least two regular anti-anginal drugs.
The original number of grafts placed at operation are shown for the three outcome groups—those without angina, those who received repeat procedure, and those with angina. The mean ages for the three outcome groups are also shown (table7).
To refer a patient for coronary artery bypass surgery is not a decision taken lightly. The outcome of the operation itself has improved considerably since its inception in the 1970s. The operative mortality in young patients between 1970 and 1980 was 7% compared with 1.2% between 1981 and 1991 in Baltimore.2 The operative mortality stated in this report was 3.9%, which is slightly higher than other reports around this period.3
Investigation and treatment of coronary artery disease in women has been a high profile topic in recent years.4 In this report 11% of those operated on were women none of whom had an exercise test. In a more recent series 20% of patients operated on were women although this cannot be extrapolated to the population of West Lothian.5 There was no difference in outcome of women in West Lothian compared with their male counterparts.
The importance of checking cholesterol preoperatively was of disputed importance at the time of the study. Only 14% of those operated on had their cholesterol checked compared with over 80% in 1986 in a series from New South Wales. These authors also reported an increase in the use of lipid regulating drugs from 2% to 37% in CABG patients from 1986 to 1994.6 Studies of angiographic progression in bypass grafts and native arteries have shown conflicting results in determining cholesterol as a risk factor.7 8 Late survival of CABG patients in Helsinki was not influenced by cholesterol values.9
No doctor likes to refer patients for procedures that may shorten their lives. This report does not compare medical treatment with surgical treatment although the proportion of patients with single and double vessel disease were similar to the early trials.1 Survival statistics for the patients of West Lothian were similar at five years to those having surgery in these trials but slightly higher at 10 years.
It is interesting that age at operation was not a predictor of survival and that no one over 70 years of age was operated on. The elderly are now not so disadvantaged with 15–33% of all operations in more recent series being carried out on patients 70–80 years old10 11 and an increase of over 200% in operations for men over 70 years between 1984 and 1989 in another centre.5 There is evidence that outcome beyond the perioperative period is not influenced by age10 although people aged over 80 in Missouri did less well.12
The prognostic indicators of poor left ventricular function and extensive disease were borne out with all patients with poor left ventricular function dying (one in his eleventh year after operation). Abnormal exercise tolerance tests, severe symptoms, and number of grafts pointed to increased likelihood of cardiac death.
Around 40% of those operated on were asymptomatic at 10 years. Not surprisingly the patients with limited disease were more likely to be asymptomatic or have a further revascularisation procedure. It is also interesting that those who had a repeat procedure were significantly younger than those survivors who had angina but no repeat procedure. This is similar to experience in Atlanta where 31% of survivors at 12 years had had a repeat procedure.13
The results from a single district are not noticeably different from the reported experience from randomised trials of surgical versus medical treatment. Relief of symptoms remains the indication for surgery. Patients and relatives should not be misled that this procedure confers longevity.