Prevalence of factor V Leiden (APCR) and other inherited thrombophilias in young patients with myocardial infarction and normal coronary arteries
- A Dacostaa,
- B Tardy-Poncetb,
- K Isaaza,
- A Cerisiera,
- P Mismettic,
- S Simitsidisc,
- J Reynaudb,
- B Tardyc,
- M Piotb,
- H Decoususc,
- D Guyotatb
- aDepartment of Cardiology, North Hospital, 42000 Saint-Etienne, France, bDepartment of Haematology, North Hospital, cDepartment of Clinical Pharmacology, Bellevue Hospital, 42000 Saint-Etienne, France
- Correspondence to: Pr K Isaaz, Hôpital Nord, CHU de Saint Etienne, Saint-Etienne Cedex 03, France.
- Accepted 16 February 1998
Abstract
Objective To investigate the role of activated protein C resistance (APCR, factor V Leiden) in coronary artery thrombosis.
Methods The prevalence of APCR and of congenital deficiencies of antithrombin III, protein C, protein S, plasminogen, and factor XII was investigated in adult patients under 45 years of age with acute myocardial infarction. The results were compared with those of a group of 53 age and sex matched control subjects.
Results Among 75 patients under the age of 45 years who were admitted from November 1994 to April 1996 for acute myocardial infarction, 22 (29.3%) had normal coronary arteriography (group I) and 53 (70.7%) had significant coronary artery disease (group II). Inherited thrombophilia was more often found in group I (4/22, 18.2%) than in group II (4/53, 7.5%) but the difference was not significant (F test: p = 0.22). The prevalence of APCR was 9.1% (2/22) in group I, 3.8% (2/53) in group 2 (p = 0.57), and 3.8% (2/53) in the normal control group (p = 0.57).
Conclusions The prevalence of congenital thrombophilias, including APCR, does not seem to be increased in young patients with myocardial infarction and normal coronary angiograms, compared with young patients with coronary atherosclerosis and with normal control subjects. However, the statistical power of the study is too low to detect a significant difference and these results are published to allow a meta-analysis of this problem in the future.
