Development and validation of a Bayesian index for predicting major adverse cardiac events with percutaneous transluminal coronary angioplasty
- aDepartment of Cardiology, Royal Sussex County Hospital, Eastern Road, Brighton BN2 5BE, UK, bDepartment of Cardiology, King's Healthcare Trust, Denmark Hill, London SE5 9RS, UK
- Dr Thomasmttwins{at}aol.com
- Accepted 11 September 2000
Abstract
OBJECTIVE To create a risk model for predicting major adverse complicating events of percutaneous transluminal coronary angioplasty (PTCA), and to test the accuracy of the model on a prospective cohort of patients
SETTING Tertiary cardiac centre
METHODS Available software can predict probabilities of events using Bayes's theorem. To establish the accuracy of these predictive tools, a Bayes table was created to evaluate major adverse complicating events (MACE)—death, emergency coronary artery bypass grafting (CABG), or Q wave infarct occurring during the in-patient episode—on the first 1500 patients in the department PTCA database (development group); the predictive value of this model was then tested with the subsequent 1000 patients (evaluation group). The following probabilities were assessed to determine their association with MACE: age, sex, left ventricular function, American Heart Association lesion morphology classification, cardiogenic shock, previous CABG, diabetes, hypertension, multivessel PTCA.
MAIN OUTCOME MEASURES To establish the discriminatory ability of the predictive index, calibration plots and receiver operating characteristic (ROC) curves were obtained to compare the development and evaluation groups.
RESULTS The ROC curve plotted to determine the discriminatory value of the Bayesian table created from the development group (n = 1500) in predicting MACE in the evaluation group (n = 1000) showed a moderately predictive area under the curve of 0.76 (SEM 0.07). This predictive accuracy was confirmed with separately constructed calibration plots.
CONCLUSIONS Accurate predictions of MACE can be identified in populations undergoing percutaneous intervention. The database used allows operators to obtain consent from patients appropriately from their own experience rather than from other published data. If a national PTCA database existed along similar lines, individual operators and interventional centres could compare themselves with nationally available data.
