Increased risk for ischaemic events is related to combined RAS polymorphism
- P P van Geela,
- Y M Pintoa,
- A H Zwindermanc,
- R H Henningb,
- A J van Bovena,
- J W Jukemad,
- A V G Bruschked,
- J J P Kasteleine,
- W H van Gilst on behalf of the REGRESS Study Groupa
- aDepartment of Cardiology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands, bDepartment of Clinical Pharmacology, University Hospital Groningen, cDepartment of Medical Statistics, University of Leiden, Leiden, Netherlands, dDepartment of Cardiology, Leiden University Medical Centre, eDepartment of Vascular Medicine, Academic Medical Centre, Amsterdam, Netherlands
- Dr van Geelp.p.geel{at}med.rug.nl
- Accepted 8 November 2000
Abstract
OBJECTIVE To determine whether the angiotensin converting enzyme (ACE) and the angiotensin II type 1 receptor (AT1R A1166C) gene polymorphism interact to increase the risk of ischaemic events, and whether this can be explained by the progression of angiographically defined coronary atherosclerosis.
DESIGN Prospective defined substudy of the lipid lowering regression trial (REGRESS).
SETTING University hospital.
PATIENTS 885 male patients with stable coronary artery disease.
MAIN OUTCOME MEASURES Incidence of ischaemic events during a two year follow up; serial quantitative coronary arteriography (mean segment diameter and minimum obstruction diameter) at baseline and after two years.
RESULTS Patients who carried both the ACE-DD and AT1R-CC genotype had significantly more ischaemic events during the two year follow up than those carrying other genotype combinations (p = 0.035, Mantel-Haenszel test for linear association). There was no association between the two genotypes and mean segment diameter or minimum obstruction diameter at baseline or after two years.
CONCLUSIONS The suggestion that ACE-DD and AT1R-CC genotypes interact to increase the risk of ischaemic events is confirmed. However, this increased risk was not accompanied by increased progression of angiographically defined coronary atherosclerosis.
