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Heart 88:298-305 doi:10.1136/heart.88.3.298
  • Education in Heart

ACUTE MYOCARDIAL INFARCTION: REPERFUSION TREATMENT

Table 2

Event rate at long term follow up, number needed to treat, and events avoided per 1000 patients treated in randomised clinical trials comparing primary angioplasty and fibrinolysis

Long term events PTCA (%) Lysis (%) p Value Odds ratio (95% CI) ARR NNT NEA × 1000
*Data on 2635 patients. Presented at the American Heart Association meeting in Atlanta, October 1999.
†The SHOCK trial did not compare PTCA with lysis, but a strategy of emergency revascularisation versus initial medical stabilisation.
‡Includes disabling stroke.
For explanation of abbreviations see table 1.
Mortality
    Weaver 6 months* 6.1 8.1 0.055 0.73 (0.52 to 0.98) 2 50 20/1000
    PAMI 2 yearsw29 6.2 9.5 0.21 Not available 3.3 30 33/1000
    Zijlstra 5±2 years16 13.4 23.9 0.01 0.54 (0.36 to 0.87) 10.5 10 100/1000
    SHOCK 6 months8† 50.3 63.1 0.027 0.80 (0.65 to 0.95) 12.8 8 125/1000
    SHOCK 1 year† 55 70 0.008 Not available 15 7 143/1000
    C-PORT 6 monthsw46 6.2 7.1 0.72 Not available 0.9 111 9/1000
Reinfarction
    Weaver 6 months 4.4 9.7 0.0001 0.43 (0.3 to 0.6) 5.3 19 53/1000
    PAMI 2 years 10.8 16.0 0.01 Not available 5.2 19 53/1000
    Zijlstra 5±2 years 6 22 0.0001 0.27 (0.15 to 0.52) 6 6 167/1000
    C-PORT 6 months 5.3 10.6 0.04 Not available 5.3 19 53/1000
Mortality or non-fatal reinfarction
    Weaver 6 months 6.8 13.4 0.0001 0.47 (0.43 to 0.7) 6.6 15 67/1000
    PAMI 2 years 14.9 23 0.034 Not available 8.1 12 83/1000
    Zijlstra 5±2 years 22 46 0.0001 0.13 (0.43 to 0.91) 24 4 250/1000
    C-PORT 6 months‡ 12.4 19.9 0.03 0.57 (0.34 to 0.95) 7.5 13 77/1000
New revascularisation
    PAMI 2 years 32.8 54 0.001 Not available 21.2 5 200/1000
    Zijlstra 5±2 years 46.4 71.1 <0.001 Not available 24.7 4 300/1000
Recurrence of ischaemia
    PAMI 2 years 36.4 48 0.026 Not available 11.6 9 111/1000
    Zijlstra 5±2 years 52 89.5 <0.001 Not available 37.5 3 333/1000

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