Improving the effectiveness of routine prenatal screening for major congenital heart defects
- 1Fetal Medicine Unit, St George's Hospital Medical School, London, UK
- 2Brompton Fetal and Paediatric Cardiology, Royal Brompton Hospital, London, UK
- Correspondence to:
Dr Julene S Carvalho, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK;
- Accepted 12 June 2002
Objective: To evaluate the effectiveness of adding outlet views to the four chamber view in routine prenatal ultrasound screening for major congenital heart defects (CHD) as performed by trained sonographers, and to compare the procedure with current practice.
Design and setting: Prospective observational study at a London teaching hospital.
Participants and methods: 9277 women booked at a single institution (80% had first trimester nuchal translucency measurement) due to have routine fetal cardiac screening using the four chamber and outflow tract views at > 18 weeks of gestation.
Main outcome measure: Identification of major CHD in chromosomally normal and abnormal pregnancies antenatally or postnatally.
Results: There were 40 abnormalities (4.3/1000), of which 30 were chromosomally normal (3.3/1000). The overall antenatal detection rate was 75% (95% confidence interval (CI) 59% to 87%) and 70% (95% CI 51% to 85%) for euploid pregnancies. Abnormal cardiac views accounted for 70% of all prenatal diagnoses, 30% of which were made at ≤ 18 weeks. The sensitivity of cardiac views during the first scan at > 18 weeks was 52%. Of all patients undergoing nuchal translucency screening, 34 had major CHD, nine with increased nuchal translucency (26.5%). Factors influencing the results of this screening programme were training and audit of operators, adequate equipment for antenatal examination, ease of access, and low threshold for referral to specialised fetal echocardiography.
Conclusion: Adding ventricular outlet views to the four chamber assessment of the heart at routine fetal anomaly scans at > 18 weeks is the most effective technique to detect CHD prenatally. The success of such a programme depends on an infrastructure committed to continuous in house training of obstetric ultrasonographers coupled with feedback from specialised fetal cardiologists, as well as adequate resource allocation to obstetric hospitals involved with antenatal screening.
Congenital heart disease accounts for the majority of deaths from congenital defects in childhood, being six times more common than chromosomal abnormalities and four times more common than neural tube defects. Prenatal detection of specific cardiac anomalies such as complete transposition of the great arteries and hypoplastic left heart syndrome has been shown to improve neonatal morbidity and surgical outcome.1,2 The overall prevalence of congenital heart defects (CHD) is estimated at 8/1000 live births.3–5 Defects usually classified as major or critical are those that are lethal or require intervention in infancy or on long term follow up. The estimated prevalence of such major abnormalities is 4/1000 live births.6,7
Historically, detailed fetal echocardiography was performed because of a positive family history for CHD, but cardiac scanning has gradually been incorporated into routine ultrasound screening programmes without strong evidence to support its implementation. Over the years, reported sensitivities for major CHD by examination of the fetal four chamber view in low risk populations at 18–23 weeks has been extremely variable, ranging form 5–60%.6–13 In the UK, the most recent national survey of over 4000 cases of major CHD reported an average antenatal detection rate of 23%.14
Adding visualisation of the ventricular outflow tracts to assessment of the four chamber view has been suggested as likely to increase the sensitivity of ultrasound screening for major CHD.15,16 However, in most previous studies selected populations were examined by specially trained medical staff15,16 who were allocated a longer time for scanning and incorporated colour flow Doppler.16 Recently, Hunter and colleagues17 instituted a policy of training sonographers involved in routine prenatal screening to obtain these views and showed an increase in detection rates. We have further developed such a programme with the aim of assessing the effectiveness of adding outlet views to the four chamber view in routine 18–23 week anomaly scans obtained by ultrasonographers.
PATIENTS AND METHODS
This was a prospective observational study of an unselected obstetric population in whom routine anomaly scans are performed at 18–23 weeks' gestation. Between January 1997 and August 1999 all women booked for antenatal care at our institution and subsequently delivered within our unit were included in the study. High risk referrals from other hospitals were excluded to eliminate bias.
Two full time and four part time sonographers working only in obstetric ultrasound performed routine ultrasound scans. The obstetric ultrasound service was situated within a unit that provided fetal medicine and echocardiography services. High resolution ultrasound equipment with a cineloop facility (ATL 3000/5000, Letchworth, UK and Acuson XP10, Uxbridge, UK) was used. In the majority of patients, nuchal translucency thickness was measured in the first trimester for screening of aneuploidy, as previously described.18 At the 18–23 week ultrasound scan, as part of the routine structural survey, the four chamber view of the fetal heart was examined. With the inception of fetal cardiology services within the unit, a comprehensive training programme overseen by the fetal cardiologist was instituted for all radiographers and obstetricians working in obstetric ultrasound.
The training was focused on two main principles. The first was that operators optimised the machine settings to obtain satisfactory cardiac images. The second was the use of a checklist for detailed assessment of the four chamber view. In addition, all sonographers were taught how to assess the outflow tracts and were encouraged to extend the echocardiographic views to include the great arteries in all patients. The time allocated for the entire fetal anomaly scan was 20 minutes per patient, with most sonographers spending an average of 2–3 minutes (maximum 5–6 minutes) to assess the fetal heart. Whenever an abnormality was detected or suspected at this level, patients were referred for a detailed cardiac scan by the fetal cardiologist. The training was complemented by two policies within the department to ensure ease of access to fetal cardiology. Firstly, in addition to those thought to be possibly or frankly abnormal, all cases with unsatisfactory views of the fetal heart were referred to the fetal cardiologist. Whenever possible the sonographer would observe the detailed cardiac scan to compare the findings with his or her own scan. Additionally, the sonographers were provided with a detailed explanation of the abnormalities encountered and were subsequently given feedback regarding postnatal outcome or postmortem results in terminated pregnancies.
Referral for echocardiography
Any deviation from the normal appearance of the fetal heart or an unsatisfactory (inability to establish normal anatomy) cardiac view was considered an indication for more detailed fetal echocardiography at any stage of pregnancy. In addition, all pregnancies considered to be at high risk of fetal cardiac problems were referred for detailed fetal echocardiography at 20–23 weeks.19–23 These included diabetic pregnancy, extracardiac fetal abnormalities detected on ultrasound, and a family history of CHD. Women with fetal nuchal translucency measurements above the 99th centile were also referred for early fetal echocardiography at 13–16 weeks.24–27
Echocardiograms were routinely recorded from neonates with signs of heart failure or cyanosis; when a heart murmur was associated with abnormal chest radiograph or ECG; or when a murmur persisted for more than six weeks in asymptomatic children. Additionally, all neonates in whom a cardiac anomaly was diagnosed in the antenatal period had postnatal echocardiography to confirm the diagnosis.
Classification of CHD
Cardiac defects were classified as major when they were potentially lethal or were severe enough to warrant termination of pregnancy, required surgery or interventional catheterisation in infancy, or were likely to need treatment on long term follow up. Patent ductus arteriosus, atrial septal defects (ostium secundum), small and restrictive ventricular septal defects, and valvar pulmonary stenosis with Doppler gradients ≤ 35 mm Hg were classified as minor for the purposes of this study.
Patient demographic, ultrasound, and pregnancy outcome data were recorded prospectively on a computer database. Chromosomal abnormalities were identified by reviewing all abnormal fetal and infant karyotypes from the regional cytogenetic laboratory database. In pregnancies with fetal cardiac malformations that resulted in intrauterine death or where the parents opted for termination of pregnancy, detailed pathological examination was requested to confirm the antenatal diagnosis. All neonatal and infant echocardiograms performed during the study period and up until April 2000 were reviewed to identify cardiac defects not diagnosed in the prenatal period. All cases of major CHD diagnosed in our institution are referred to a single cardiac centre. Neonatal, obstetric, and cardiothoracic teams met weekly to exchange information regarding recently diagnosed cardiac anomalies. The cardiothoracic database of the tertiary cardiac centre was also reviewed to identify patients from our unit undergoing long term follow up, interventional cardiac catheterisation, or surgery.
During the study period 9277 women booked for antenatal care delivered within the unit. The mean maternal age of the study population was 27 years (range 15–44 years). First trimester nuchal translucency was measured in 7384 (79.6%) pregnancies.
Referrals for echocardiography were made in 890 (9.6%) pregnancies and 517 children. Figure 1 shows the indications for fetal echocardiography. During the study period, the most common reason for referral was the presence of intracardiac echogenic foci (n = 235, 26.4%) and the least frequent reason was the finding of abnormal cardiac views (n = 53, 5.9%). The number of referrals for echocardiography fell from 26 per month (9.1/100 anomaly scans) at the beginning of the study to 23 per month (8/100 anomaly scans) at the end of the study.
Major defects of the heart and great arteries were identified in 40 pregnancies (4.3/1000 pregnancies) of which 30 were chromosomally normal (3.3/1000 pregnancies). Thirty of these cases (75%) were diagnosed antenatally (table 1) and 10 postnatally (table 2). CHD were diagnosed in 70% of the chromosomally normal fetuses (21/30) and in 90% of aneuploid fetuses (9/10; tables 1, 2, and 3). Most major CHD detected antenatally were diagnosed because of either abnormal or unsatisfactory cardiac views (21/30 or 70%), the majority during scans carried out after 18 weeks (19/30 or 63%), including two fetuses who also had increased nuchal translucency. Of these, 16 were suspected during the first anomaly scan and three on follow up examinations carried out for other reasons. Two were found to have abnormal cardiac findings before 18 weeks. One presented with fetal bradycardia during routine first trimester scan at 12 weeks (normal nuchal translucency) and in the other an abnormal four chamber view was detected at 17 weeks during a scan carried out for fetal viability because of maternal bleeding (previous nuchal translucency of 2.7 mm).
Thus, abnormal or unsatisfactory cardiac views at any stage during pregnancy accounted for 70% of all prenatal diagnoses (21/30) and for 53% of all cases of CHD (21/40). After exclusion of those cases of CHD diagnosed in early pregnancy (≤ 18 weeks), the relative contribution of the sonographers's assessment of the fetal heart at the time of the routine anomaly scan (> 18 weeks) was 76% of all prenatal diagnoses (16/21) and 52% of all cases seen who had an anomaly scan after 18 weeks (16/31). Nine cases were diagnosed before the routine 18–23 week scan, seven of which were associated with increased nuchal translucency. Overall, the nuchal thickness was increased in 27% of cases of CHD (9/34) and accounted for 15% (4/26) of chromosomally normal pregnancies where the mother underwent a scan at 12–14 weeks.
During the study period, 44 chromosomally abnormal pregnancies were diagnosed, of which 10 were diagnosed as having major CHD. In seven the defect was minor or absent. Twenty seven pregnancies were terminated before 14 weeks, before a fetal anomaly scan or fetal echocardiography was performed. A chromosomal abnormality was diagnosed because of increased nuchal translucency measurement in 32, because of multiple markers on anomaly scan in nine, and postnatally in the remaining three. Table 2 shows the indications for echocardiography in all cases diagnosed postnatally.
The present study has shown that routine prenatal screening for major CHD can be highly effective in a low risk population. The 75% detection rate of the current study is the highest reported with routine ultrasound screening, where ascertainment of the prevalence of CHD was thorough, including complete data on postnatal follow up. Although the data in large unselected obstetric populations were complete, the absolute number of abnormalities encountered is not large: 40 cases of major CHD, 30 of which were diagnosed antenatally. Thus, some caution should be exercised in extrapolating the detection rate to bigger populations. Our 95% confidence interval, however, varied from 59% to 87%.
Prevalence of CHD and case ascertainment
The overall prevalence for major CHD in this study was 4.3/1000 pregnancies (3.3/1000 in chromosomally normal pregnancies). This figure is consistent with previous population reports on prevalence, indicating that ascertainment of fetal and infant CHD was rigorous in this study.3–5 Bull14 recently conducted a multicentre study of 17 paediatric cardiac centres reporting 4799 major CHD in fetuses and infants delivered between 1993 and 1995. She reported a prevalence of 2.1/1000 pregnancies, although she noted that this may have been an underestimate because of underreporting of fetal diagnoses and necropsy results. Hunter and colleagues17 reported prevalence rates between 2.6 and 3.3 /1000 live births between 1994 and 1997. Low prevalence of major CHD is a consistent problem in many previous studies, such that sensitivities as high as 55–63% have been reported in studies where the CHD prevalence is as low as 1.3/1000, presumably explained by the lack of adequate case ascertainment.11–13 Single centre studies, such as the current one, that included pathological examinations, neonatal echocardiography, and long term paediatric follow up have produced the most accurate estimates of CHD prevalence. Rustico and colleagues15 and Tegnander and associates8 used similar methods in large, prospective series and reported prevalences of 4.4 and 3.4/1000 pregnancies, respectively.
Extended views and operator training
Only two previous studies have evaluated the influence of sonographer training within the context of a routine screening programme. Tegnander and colleagues8 specifically investigated the value of operator training in a single unit with good long term follow up from a comprehensive child health programme. They reported an increase in the sensitivity from 18% to 26% with operator training to obtain a four chamber view.8 More recently, Hunter and colleagues17 carried out a four year prospective multicentre study to evaluate the effect of operator training on sensitivity of CHD screening. The authors reported an improvement in the detection rate for major CHD from 17% to 36% after a two year training period to enable sonographers to visualise the four chamber and outflow tract views.17 These data suggest that operator training and routine visualisation of the outflow tracts alone are unlikely to explain the sensitivity of 75% for CHD in this study.
Indications for referral for detailed fetal echocardiography
Approximately 20% of referrals were made because of an abnormal or unsatisfactory cardiac view at the routine fetal anomaly scan. Nonetheless, this resulted in the detection of 55% of major CHD. Although maternal diabetes and a family history of CHD also accounted for 20% of referrals, only one case (3.3%) of major CHD was detected from these scans. The most common reason for referral (26%) was the detection of isolated intracardiac echogenic foci, as dictated by the established protocol within the unit at the time of the study. The finding that the prevalence of major CHD in these fetuses appears to be no higher than in the rest of the population has now led to cessation of this practice. As fetuses with isolated intracardiac echogenic foci are no longer referred, approximately 5% of pregnancies now receive a detailed cardiac scan. It is important to note that increased nuchal translucency remains an important indication for fetal echocardiography, with 31% of major CHD diagnosed in this group. Although the sensitivity of this marker is lower than originally predicted, increased nuchal translucency above the 99th centile should mandate referral for detailed fetal echocardiography.24,25
Examination time and access to echocardiography
The reasons for the relatively high detection rate in this study deserve further analysis. Constraints placed on health service resources in the UK dictate that most routine fetal ultrasound examinations be performed in a limited amount of time and sometimes with inadequate equipment. In this study, sonographers were scheduled 20 minutes per fetal anomaly scan and they used ultrasound machines of a good standard, optimised for fetal cardiac examination.
The ease of access and the high frequency of referral in this study reflect the availability of fetal echocardiography within the same unit. The low threshold for fetal echocardiography and subsequent direct feedback enables sonographers gradually to build up their skills and confidence in detecting cardiac abnormalities. The sensitivity for CHD may have been relatively lower in the study carried out by Hunter and colleagues17 because it was based on data from 16 centres covering a large geographic area. The latter features mitigate against patient access and this is reflected by the finding that referrals for fetal echocardiography were low (1%) compared with 8% in the current study. Few other studies of routine CHD screening have estimated the ease of access to and referral rate for fetal echocardiography following the anomaly scan,6–8 despite the obvious value of fetal cardiology services within a fetal medicine department.
Our data indicate that routine antenatal assessment of the four chambers and great vessels between 18 and 23 weeks is effective in the prenatal detection of major CHD. The sonographer performing the routine anomaly scan remains the major contributor to prenatal detection of major CHD. Proper equipment to allow optimisation of cardiac views, adequate examination time, and ease of access to tertiary level fetal cardiology services obviously influence the extent to which such a service is successful. While the need for improved antenatal detection of major CHD is known, the adoption of a screening programme similar to ours has significant resource implications for health care providers. Even a slight increase in scanning time may be more difficult to implement than training experienced sonographers to assess the ventricular outflow tracts and the four chamber view competently. Importantly, the success of this screening programme cannot be divorced from the ease of access and relatively high referral for detailed fetal echocardiography. The limited availability of such tertiary fetal cardiology specialists and services nationally is also likely to affect the success of other antenatal CHD screening programmes.
We thank the sonographers, midwives, and doctors in the Fetal Medicine Department at St George's Hospital, without whose contribution this work would not have been completed. Funding: EM was supported by a grant from St George's Hospital Trustees (grant 00.6.58). JSC was partially funded by the Hyman Marks Research Fund, Royal Brompton Hospital.