Cardiac remodelling in end stage heart failure: upregulation of matrix metalloproteinase (MMP) irrespective of the underlying disease, and evidence for a direct inhibitory effect of ACE inhibitors on MMP

D Reinhardt; H H Sigusch; J Henβe; S C Tyagi; R Körfer; H R Figulla

doi:10.1136/heart.88.5.525

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Cardiac remodelling in end stage heart failure: upregulation of matrix metalloproteinase (MMP) irrespective of the underlying disease, and evidence for a direct inhibitory effect of ACE inhibitors on MMP

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	Abstract	Full	Pdf
Oct 2002	95	158	87
Nov 2002	64	146	79
Dec 2002	16	89	44
Jan 2003	12	108	58
Feb 2003	9	78	24
Mar 2003	9	67	24
Apr 2003	9	74	31
May 2003	11	55	20
Jun 2003	3	35	21
Jul 2003	17	43	22
Aug 2003	15	39	13
Sep 2003	14	36	14
Oct 2003	32	74	24
Nov 2003	24	42	5
Dec 2003	30	25	8
Jan 2004	16	36	9
Feb 2004	25	45	25
Mar 2004	22	35	17
Apr 2004	28	37	15
May 2004	45	69	21
Jun 2004	47	49	12
Jul 2004	58	73	26
Aug 2004	50	64	15
Sep 2004	35	79	35
Oct 2004	11	72	34
Nov 2004	28	93	40
Dec 2004	20	75	24
Jan 2005	34	126	29
Feb 2005	23	74	29
Mar 2005	19	51	30
Apr 2005	27	45	24
May 2005	15	59	35
Jun 2005	10	42	25
Jul 2005	19	43	14
Aug 2005	19	40	24
Sep 2005	26	47	41
Oct 2005	30	51	32
Nov 2005	38	58	34
Dec 2005	26	50	20
Jan 2006	17	38	25
Feb 2006	14	47	27
Mar 2006	8	60	20
Apr 2006	11	51	17
May 2006	17	42	16
Jun 2006	14	33	23
Jul 2006	12	28	11
Aug 2006	22	23	14
Sep 2006	29	34	16
Oct 2006	21	37	26
Nov 2006	15	30	21
Dec 2006	17	27	23
Jan 2007	6	38	31
Feb 2007	12	40	18
Mar 2007	34	57	40
Apr 2007	43	16	13
May 2007	41	23	23
Jun 2007	46	19	20
Jul 2007	23	16	11
Aug 2007	16	16	11
Sep 2007	21	10	9
Oct 2007	35	13	13
Nov 2007	38	13	13
Dec 2007	27	4	4
Jan 2008	11	4	6
Feb 2008	6	5	3
Mar 2008	29	7	15
Apr 2008	51	16	18
May 2008	51	4	11
Jun 2008	41	9	12
Jul 2008	43	10	10
Aug 2008	48	8	9
Sep 2008	51	4	4
Oct 2008	48	6	5
Nov 2008	31	6	3
Dec 2008	29	5	5
Jan 2009	42	4	8
Feb 2009	51	13	12
Mar 2009	29	14	6
Apr 2009	31	13	6
May 2009	19	15	3
Jun 2009	18	8	6
Jul 2009	34	18	8
Aug 2009	23	15	4
Sep 2009	32	18	4
Oct 2009	31	20	7
Nov 2009	33	7	3
Dec 2009	96	7	6
Jan 2010	234	10	9
Feb 2010	192	4	5
Mar 2010	216	6	10
Apr 2010	165	15	9
May 2010	156	7	5
Jun 2010	90	12	11
Jul 2010	41	4	6
Aug 2010	91	29	20
Sep 2010	169	47	55
Oct 2010	112	23	22
Nov 2010	39	8	6
Dec 2010	21	25	7
Jan 2011	29	15	8
Feb 2011	31	12	2
Mar 2011	36	16	13
Apr 2011	37	11	3
May 2011	70	12	1
Jun 2011	37	7	22
Jul 2011	29	3	46
Aug 2011	18	14	11
Sep 2011	31	15	5
Oct 2011	32	7	8
Nov 2011	32	9	3
Dec 2011	26	21	8
Jan 2012	33	38	7
Feb 2012	17	14	9
Mar 2012	53	12	21
Apr 2012	21	18	28
May 2012	28	24	17
Jun 2012	21	11	9
Jul 2012	18	25	15
Aug 2012	24	27	28
Sep 2012	28	42	12
Oct 2012	48	35	20
Nov 2012	34	25	11
Dec 2012	21	11	6
Jan 2013	42	8	7
Feb 2013	43	22	11
Mar 2013	51	91	8
Apr 2013	25	19	10
May 2013	45	6	8
Jun 2013	18	21	7
Jul 2013	39	7	1
Aug 2013	323	6	2
Sep 2013	190	43	2
Oct 2013	248	31	2
Nov 2013	204	33	11
Dec 2013	87	13	3
Jan 2014	17	6	3
Feb 2014	24	5	4
Mar 2014	32	7	11
Apr 2014	22	4	4
May 2014	30	7	11
Jun 2014	36	8	8
Jul 2014	17	14	4
Aug 2014	10	6	4
Sep 2014	9	8	2
Oct 2014	20	5	7
Nov 2014	23	5	4
Dec 2014	13	2	3
Jan 2015	27	3	2
Feb 2015	16	4	7
Mar 2015	9	3	0
Apr 2015	13	0	3
May 2015	13	2	2
Jun 2015	15	0	3
Jul 2015	19	2	2
Aug 2015	15	2	5
Sep 2015	25	2	5
Oct 2015	15	3	3
Nov 2015	16	4	4
Dec 2015	22	5	1
Jan 2016	27	6	5
Feb 2016	27	11	6
Mar 2016	22	2	7
Apr 2016	19	3	5
May 2016	11	13	7
Jun 2016	10	3	7
Jul 2016	18	4	3
Aug 2016	14	3	5
Sep 2016	16	5	7
Oct 2016	29	5	7
Nov 2016	7	3	4
Dec 2016	9	3	2
Jan 2017	14	0	5
Feb 2017	6	2	6
Mar 2017	15	23	5
Apr 2017	3	21	3
May 2017	4	12	4
Jun 2017	3	9	6
Jul 2017	13	8	3
Aug 2017	24	14	3
Sep 2017	22	6	1
Oct 2017	25	11	5
Nov 2017	27	9	8
Dec 2017	29	17	9
Jan 2018	28	16	6
Feb 2018	15	5	3
Mar 2018	31	9	37
Apr 2018	19	11	8
May 2018	37	19	4
Jun 2018	37	15	6
Jul 2018	21	11	6
Aug 2018	48	16	5
Sep 2018	22	12	4
Oct 2018	21	9	6
Nov 2018	24	10	11
Dec 2018	25	17	4
Jan 2019	22	7	10
Feb 2019	11	11	5
Mar 2019	24	12	9
Apr 2019	27	13	8
May 2019	16	7	6
Jun 2019	15	7	8
Jul 2019	12	6	5
Aug 2019	13	5	5
Sep 2019	24	8	16
Oct 2019	4	2	3
Nov 2019	17	6	5
Dec 2019	20	8	9
Jan 2020	31	9	5
Feb 2020	21	5	3
Mar 2020	20	16	6
Apr 2020	16	11	4
May 2020	21	15	25
Jun 2020	9	8	10
Jul 2020	22	13	8
Aug 2020	10	10	9
Sep 2020	36	9	8
Oct 2020	24	15	9
Nov 2020	19	9	11
Dec 2020	22	6	5
Jan 2021	15	10	8
Feb 2021	14	6	6
Mar 2021	21	11	9
Apr 2021	30	12	9
May 2021	10	7	3
Jun 2021	5	5	5
Jul 2021	84	84	7
Aug 2021	119	119	7
Sep 2021	54	54	9
Oct 2021	43	33	17
Nov 2021	31	25	18
Dec 2021	29	19	1
Jan 2022	20	16	5
Feb 2022	47	33	11
Mar 2022	59	32	15
Apr 2022	19	9	1
May 2022	25	13	15
Jun 2022	19	9	8
Jul 2022	22	15	3
Aug 2022	57	40	9
Sep 2022	12	5	4
Oct 2022	53	33	11
Nov 2022	27	11	9
Dec 2022	22	14	4
Jan 2023	34	24	9
Feb 2023	45	33	4
Mar 2023	28	20	5
Apr 2023	17	7	4
May 2023	19	9	8
Jun 2023	25	9	5
Jul 2023	28	10	9
Aug 2023	20	8	8
Sep 2023	21	13	2
Oct 2023	41	27	12
Nov 2023	43	25	3
Dec 2023	47	1	1
Jan 2024	63	2	0
Feb 2024	24	0	0
Mar 2024	193	0	1
Total	9164	5818	3035

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