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A 62 year old man developed recurrent stable angina 16 years after coronary artery bypass grafting (CABG) with saphenous vein grafts to the left anterior descending and right (RCA) coronary arteries. Angiography showed a long critical stenosis in the mid portion of the RCA vein graft. A 28 mm Wallstent was deployed with a good angiographic and clinical result. However, the patient developed unstable angina 11 months later, and angiography now showed the RCA vein graft to be occluded by a new ostial lesion. Attempts at further angioplasty were not successful, so redo CABG was performed. A new saphenous vein graft was anastomosed to the distal RCA, and the original occluded vein graft was resected. This vessel was fixed, embedded in methyl methacrylate resin, and sections through the stented segment were cut with a diamond saw. Panel A shows a low power (×2.5) photomicrograph of the stented vein graft section, stained with haematoxylin and eosin. There is a moderate degree of circumferential intimal hyperplasia, with a large eccentric atherosclerotic plaque between the stent struts and lumen (*). Panel B shows a high power (×10) view of the atherosclerotic plaque using oil red O to stain lipid deposits red/orange. Lipid laden macrophages (*) are localised around the stent struts, and a hypocellular fibrous cap is interposed between these chronic inflammatory cells and the vessel lumen. This case shows that features of classical atherosclerosis, in addition to intimal hyperplasia, may contribute to in-stent restenosis in human saphenous vein grafts.