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Protein C deficiency manifesting as an acute myocardial infarction and ischaemic stroke
  1. I Y Tiong1,
  2. M L Alkotob1,
  3. S Ghaffari2
  1. 1Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
  2. 2Department of Cardiovascular Medicine, Cleveland Clinic Foundation
  1. Correspondence to:
    Dr S Ghaffari, Section of Cardiovascular Imaging, Desk F 15, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA;
    ghaffas{at}ccf.org

Abstract

Protein C deficiency is a disorder in the coagulation cascade that results in predominantly venous thromboembolism. However, recent studies have implicated this disorder as a possible contributor to arterial thrombosis, especially myocardial infarction. There are six reported cases of myocardial infarction secondary to protein C deficiency in the literature. This is the first report of myocardial infarction and ischaemic stroke in the same patient as a manifestation of protein C deficiency. The investigation of hypercoagulable state is an essential component of the investigation of young patients with myocardial infarction.

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    BMJ Publishing Group Ltd and British Cardiovascular Society