The variation of plasma concentrations of a novel, adipocyte derived protein, adiponectin, in patients with acute myocardial infarction
- S Kojima1,
- T Funahashi4,
- T Sakamoto1,
- S Miyamoto1,
- H Soejima1,
- J Hokamaki1,
- I Kajiwara1,
- S Sugiyama1,
- M Yoshimura1,
- K Fujimoto3,
- Y Miyao3,
- H Suefuji3,
- A Kitagawa2,
- N Ouchi4,
- S Kihara4,
- Y Matsuzawa4,
- H Ogawa1
- 1Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
- 2Department of Pharmacy, Kumamoto University School of Medicine, Kumamoto, Japan
- 3Department of Cardiovascular Medicine, Kumamoto National Hospital, Kumamoto, Japan
- 4Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
- Correspondence to:
Dr Hisao Ogawa, Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto City, 860-8556 Japan;
ogawah{at}kumamoto-u.ac.jp
- AMI, acute myocardial infarction
- BMI, body mass index
- CRP, C reactive protein
- TNFα, tumour necrosis factor α
Adiponectin is a new member of adipocyte derived proteins belonging to the soluble defence collagens.1 Plasma adiponectin concentrations in obese subjects are decreased in spite of an adipose specific expression.1 More interestingly, the patients with chronic coronary artery disease exhibited lower plasma adiponectin concentrations compared to body mass index (BMI) matched control subjects.2 On the other hand, adiponectin accumulates in the vascular subendothelial space when the endothelial barrier is damaged.3 In vitro, adiponectin suppresses the expression of adhesion molecules in the vascular endothelial cells and cytokine production from macrophages.2,4 Therefore, the molecule may be involved in the inflammation and tissue repairing processes.
Acute coronary syndrome is often precipitated by acute thrombosis.5 It is commonly accepted that the rupture or the erosion of plaques by the inflammatory process leads to coronary thrombosis and acute myocardial infarction (AMI). The C reactive protein (CRP) concentrations in the acute phase are suggested to reflect pre-existing coronary plaque instability associated with the onset of AMI. The significance of adiponectin in acute coronary syndrome has never been investigated. In the present study, we examined the serial change in plasma adiponectin concentrations and its relation to plasma CRP concentration in …
