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Fatal fulminant myocarditis caused by disseminated mucormycosis
  1. A Basti1,
  2. S Taylor2,
  3. M Tschopp3,
  4. J Sztajzel1
  1. 1Cardiology Center, University Hospital Geneva, Geneva, Switzerland
  2. 2Department of Pathology, University Hospital Geneva
  3. 3Medical Clinics, Department of Internal Medicine, University Hospital Geneva
  1. Correspondence to:
    Dr Juan Sztajzel
    Cardiology Center, University Hospital Geneva, 24, rue Micheli-du-Crest, 1211 Geneva 4, Switzerland; juan.sztajzelhcuge.ch

Abstract

Acute fulminant myocarditis is a critical clinical condition with sudden onset of severe congestive heart failure followed by severe haemodynamic deterioration. Instituting early left ventricular support may improve outcome and result in better long term survival. The case of an immunocompromised patient who developed acute fulminant myocarditis in the setting of disseminated mucormycosis is presented.

  • fulminant myocarditis
  • severe haemodynamic deterioration
  • mechanical circulatory support
  • ST segment elevation
  • immunocompromised patient

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CASE REPORT

A 40 year old woman with aplastic anaemia treated with immunosuppressive agents and steroids, who had undergone a medullary cell transplant in February 2003, was admitted to our hospital on 12 April 2003 because of fatigue, nausea, vomiting, dehydration, and renal insufficiency. The patient subsequently developed a staphylococcal bacteraemia, which was treated with antibiotics; however, she continued to have fever on the following days. Therefore, an echocardiogram was recorded, which was normal. On 27 April, ST segment elevation was observed on continuous ECG monitoring, although the patient was asymptomatic. A 12 lead ECG (fig 1) showed concave ST elevation in almost all leads. The second echocardiogram showed a normal left ventricular cavity without hypertrophy and preserved systolic function, no valvar vegetations, no pulmonary hypertension, and no significant pericardial effusion. Because of the increase of cardiac enzymes (creatine kinase MB and troponin) the patient was taken to the intensive care unit with a diagnosis of myopericarditis.

Figure 1

 Twelve lead ECG showing concave ST elevation in almost all leads.

During the night the patient rapidly developed severe heart failure. The echocardiogram recorded at that time, eight hours after the second one, showed severe dilatation of the left ventricle with akinesia of almost all segments and severe systolic dysfunction. The patient had cardiopulmonary arrest and electromechanical dissociation, necessitating cardiopulmonary resuscitation. Because of the patient’s general poor condition, including pancytopenia, septicaemia, and severe hypoxaemia, we decided against providing mechanical circulatory support. The patient died after 90 minutes of cardiopulmonary resuscitation.

Necropsy showed disseminated mucormycosis in the lungs, heart, liver, kidneys, brain, and skin. Macroscopically and histologically, there was mycotic infiltration of the pericardium (fig 2A, B) and of the myocardium with zones of freshly infarcted tissue (fig 3A, B).

Figure 2

 (A) Epicardial necrotic plaques (arrows) caused by mycotic embolisation. (B) Mycelium (arrow) crossing the vascular wall and infiltrating the myocardium. Contraction bands correspond to necrotic myocytes.

Figure 3

 (A) White zones (arrows) of mycotic infiltration and red zones (arrowheads) of freshly infarcted zones. (B) Irregular tubular structures corresponding to mycotic filaments (arrows) in intramyocardial vessels.

DISCUSSION

This immunocompromised patient died of an acute fulminant myocarditis in the setting of disseminated mucormycosis. Mucormycosis is a fungal infection and may affect immunocompromised patients with haematological malignancies.1,2 Because of its variable clinical manifestations mucormycosis is not diagnosed during life, rendering the disease most often fatal, although in a few cases successful treatment has been reported.3

In our patient, the fungal infection had disseminated into the pericardium and the myocardium with rapid deterioration of left ventricular function. Clinically, we initially observed only the presence of ST segment elevation on the ECG, with no particular symptoms. Possible diagnoses for these ECG changes were acute myocardial infarction and acute pericarditis associated or not with myocarditis (fig 4). Our patient had concave ST elevation with depression of the PR interval, most probably corresponding to acute pericarditis. Because cardiac enzyme concentrations were increased myopericarditis was diagnosed. A coronary angiogram was not made because the patient had no chest pain and because of the very low probability of coronary artery disease.

Figure 4

 (A) Concave ST elevation caused by acute pericarditis. (B) Convex ST elevation in the setting of acute transmural ischaemia.

Acute myocarditis is an inflammatory disease of the myocardium and may be of a common or a fulminant type. Acute fulminant myocarditis is characterised by notable myocardial inflammation with sudden onset of severe congestive heart failure followed by severe haemodynamic deterioration.4 Although acute fulminant myocarditis is a critical clinical condition at presentation, data from a study5 have shown that patients with this disorder may have a better long term survival than those with acute common myocarditis. Echocardiographic findings in patients with fulminant myocarditis at presentation have shown a non-dilated left ventricular cavity with a thickened and hypocontractile left ventricle. Patients with acute common myocarditis had a dilated left ventricle, with normal thickness, but decreased systolic function.6 These findings may be one of the reasons for the better prognosis during follow up of patients with acute fulminant myocarditis. Taking into account these data some authors have suggested the use of early short term circulatory support with left ventricular assist devices combined with intensive medical treatment.7,8

The case of our patient illustrates the very rapid and dramatic deterioration of left ventricular function, which had still been normal several hours earlier, and raises the question of what is the threshold for instituting early ventricular support, particularly in very ill patients.

REFERENCES

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