Article Text


Long term outcome up to 30 years after the Mustard or Senning operation: a nationwide multicentre study in Belgium
  1. P Moons1,*,
  2. M Gewillig2,
  3. T Sluysmans3,
  4. H Verhaaren4,
  5. P Viart5,
  6. M Massin6,
  7. B Suys7,
  8. W Budts2,
  9. A Pasquet3,
  10. D De Wolf4,
  11. A Vliers8
  1. 1Centre for Health Services and Nursing Research, Katholieke Universiteit Leuven, Leuven, Belgium
  2. 2Division of Congenital Cardiology, University Hospitals of Leuven, Leuven, Belgium
  3. 3Department of Paediatric Cardiology, Cliniques Universitaires Saint Luc, Brussels, Belgium
  4. 4Heart Centre, Ghent University Hospital, Ghent, Belgium
  5. 5Department of Paediatric Cardiology, Hôpital Universitaire Des Enfants Reine Fabiola, Brussels, Belgium
  6. 6Division Paediatric Cardiology, University of Liège at CHR Citadelle, Liège, Belgium
  7. 7Department of Paediatric Cardiology, University Hospital of Antwerp, Edegem, Belgium
  8. 8Belgian National Foundation for Research in Paediatric Cardiology, Halle, Belgium
  1. Correspondence to:
    Dr Philip Moons
    Centre for Health Services and Nursing Research, Katholieke Universiteit Leuven, Kapucijnenvoer 35/4, B-3000 Leuven, Belgium;


Objective: To assess long term outcome of patients who underwent Mustard or Senning repair for transposition of the great arteries up to 30 years earlier.

Design: Retrospective review of medical records.

Setting: The six university hospitals in Belgium with paediatric cardiology departments.

Patients: 339 patients were reviewed, of whom 124 underwent the Mustard procedure and 215 the Senning procedure. This represents almost the entire population of patients in Belgium with either simple or complex transposition.

Main outcome measures: Mortality, morbidity, functional abilities, social integration.

Results: Overall mortality was 24.2%. Early mortality (⩽ 30 days after surgery) accounted for 16.5%, late mortality for 7.7%. Actuarial survival of early survivors at 10, 20, and 30 years after surgery was 91.7%, 88.6%, and 79.3%, respectively. Patients in the Senning cohort had a slightly better survival rate than those in the Mustard cohort (NS). Baffle obstruction occurred more often after Mustard repair (15.3%) than after the Senning procedure (1.4%). Arrhythmia-free survival did not differ between the two cohorts, but was determined by the complexity of the transposition. Survivors of the Senning cohort had better functional status, and tended to engage in more sports activities.

Conclusions: The long term outcome for patients surviving the Mustard or Senning operation was favourable in terms of late mortality, morbidity, functional, and social status. Overall mortality in the Senning cohort did not differ from the Mustard group, but Senning patients had better functional status, greater participation in sports activities, and fewer baffle related problems.

  • congenital heart disease
  • transposition of the great vessels
  • surgical treatment
  • outcome

Statistics from

From the early 1960s to the mid 1980s, the Mustard and Senning procedures were the treatment of choice for transposition of the great arteries (d-TGA). However, because of complications such as right ventricular failure, arrhythmias, tricuspid valve dysfunction, baffle related problems, and sudden death,1 these procedures were replaced by arterial switch operations. Nonetheless, most patients who underwent a Mustard or Senning operation are approaching or have reached adulthood. As a result, cardiologists engaged in the follow up of these patients must deal with multiple residua and sequelae, as well as functional problems associated with these two procedures.

In the last few years there have been several studies reporting long term effects of atrial inflow correction.2–13 All but one of these12 collected data from single centres, thus overlooking the variability inherent in clinical practice, in particular the different surgical techniques applied in these cases. Moreover, the follow up period in most of these studies was limited to approximately 20 years after atrial repair. Information about the long term follow up, up to 30 years, is sparse.4

In the present nationwide multicentre study we therefore undertook a comprehensive evaluation of the long term outcome of patients who underwent Mustard or Senning operations, and compared the outcomes of the two procedures. Long term results were assessed in terms of mortality, morbidity, functional abilities, and social integration.


Study population

We carried out a retrospective analysis of the medical records of patients who had either simple or complex d-TGA and who had undergone either Mustard or Senning operations. All the patients in this study underwent the operation or received postoperative follow up in one of six paediatric cardiology centres in Belgium. The population of Belgium is approximately 10 million.

The first Mustard procedure in this cohort was done in 1970; the routine use of the technique was abandoned in 1982. In 1977, Senning operations emerged as the treatment of choice in Belgium and were done in some centres until 1993 (fig 1). After 1993, only three patients had the Mustard operation and two the Senning operation. Different surgical techniques were instituted according to the preferences and experience of the local cardiac surgeons. Follow up of the patients was provided by paediatric cardiologists or adult cardiologists with specific training in congenital heart disease, depending on their availability in the respective centres.

Figure 1

Cumulative numbers of Mustard and Senning operations undertaken each year between 1970 and 1998.

In all, 339 patients were included in the study. Demographic and clinical characteristics of the patients are summarised in table 1. The male to female ratio was 2 to 1. Simple d-TGA, without concomitant anomalies or with only minor heart defects (for example, atrial septal defect, ventricular septal defect not requiring surgical closure, persisting arterial duct, or left ventricle outflow tract obstruction) was present in 244 patients. Transposition in the remaining 95 patients was associated with other cardiac lesions, such as large ventricular septal defects, pulmonary valve stenosis, coarctation of the aorta, or other less frequent abnormalities.

Table 1

Demographic and clinical characteristics of 339 patients undergoing a Mustard or Senning operation

Blalock-Hanlon septectomy was done in 69 patients. Of these, 28 (40.6%) underwent the Rashkind procedure before septectomy. Rashkind septostomy was done in 233 patients. Three patients from the Mustard cohort were converted to Senning at 4.3, 4.6, and 11.6 years after the initial Mustard operation, respectively. For further analysis, these patients were placed in the Mustard cohort. Two patients (0.6%) were referred for arterial switch conversion at 2.1 and 4.8 years after the Senning operation. Two patients (0.6%) underwent heart transplantation at 17.4 and 20.5 years after the Mustard procedure. Fourteen Mustard patients needed a first redo and two needed a second redo, because of venous pathway obstruction (n  =  9), pulmonary vein obstruction (n  =  6), or baffle leak (n  =  1). Three Senning patients required a Senning redo operation because of baffle leakage.

Measurement and definitions

The patients’ history and case notes were reviewed to obtain information on concomitant anomalies, interventions, and operations before and after the atrial switch procedure, postoperative complications, survival after repair, occurrence of arrhythmias during the postoperative course, functional status of the patients, and the dates of diagnoses or interventions. This information was based on follow up reports, ECG, ambulatory ECG (24 hour), echocardiogram reports, and catheterisation data. All diagnostic categories, interventions, complications, and arrhythmias were recorded using the short list of EPC codes of the Association for European Paediatric Cardiology (AEPC).14 Implementation of these codes allowed standardisation of data collection across all the participating centres.

The functional status of surviving individuals was assessed during the most recent examination. Variables defining functional status included educational level, employment status, level and type of sports activity performed, New York Heart Association (NYHA) functional class,15 and ability index.16 The ability index was deduced from descriptions assessing physical and social function of each patient. Sports activities were categorised into three levels of intensity17: mild, moderate, and high. Examples of mild intensity sports are billiards, bowling, and golf; moderate intensity sports include badminton, cycling, gymnastics, and dancing; and high intensity sports include basketball and football.17

Arrhythmia-free survival was determined in patients surviving the early postoperative period. It was defined as survival after the Mustard or Senning operation without any episode of rhythm or conduction disturbance. In this analysis the following were considered to be rhythm disturbance events: persistent or temporary loss of sinus rhythm; pacemaker implantation; prescription of antiarrhythmic drugs; heart transplantation; episodes of sustained or non-sustained supraventricular rhythm disturbance (atrial flutter, atrial fibrillation, sinus node dysfunction, paroxysmal atrial tachycardia, sinus bradycardia); atrioventricular (AV) rhythm disturbances (AV junctional tachycardia, or junctional escape bradycardia); ventricular rhythm disturbances (ventricular tachycardia, ventricular flutter, frequent premature ventricular complexes); conduction disorders (first degree AV block, second degree AV block, complete AV block, complete right bundle branch block); and late mortality that was firmly or potentially related to arrhythmias.

Systemic right ventricular function was evaluated by visual and qualitative assessment of cross sectional echocardiograms. Systemic ventricular function was graded as either normal or mildly disturbed, moderately depressed, or severely depressed, based on descriptions in the medical records.

Tricuspid valve regurgitation data from the echocardiography reports were also collected at the final examination. A rating of 0/4 or 1/4 corresponded to no or mild regurgitation, 2/4 reflected moderate regurgitation, and 3/4 or 4/4 was regarded as severe regurgitation. The methods used to assess ventricular function and tricuspid valve competence in this retrospective study were limited in terms of objective quantifiable measurements. However, an echocardiogram was done systematically during clinical follow up, in contrast to magnetic resonance imaging or angiographic evaluation.

Mortality data were divided into two categories: early and late. Early mortality was defined as death within 30 days following surgery, and late mortality as death occurring after the first 30 days. Patients surviving 30 days after the repair surgery were referred to as early survivors, while patients who are still alive are late survivors.

Statistical analysis

Descriptive statistics for nominal data were expressed in absolute numbers and percentages. After checking for normality, mean values and standard deviations were calculated for normally distributed continuous variables, and medians and quartiles were computed for continuous variables with a non-normal distribution. Univariate group comparisons for nominal data were done using the χ2 test, or Fisher’s exact test if the assumptions for χ2 were not fulfilled. Non-parametric correlations were calculated using Spearman’s ρ.

Kaplan–Meier curves were plotted to describe the cumulative probability of survival and the probability for arrhythmia-free survival. The log rank test was used to compare survival curves according to the type of atrial repair and the complexity of the transposition.

As the occurrence of rhythm disturbances, systemic ventricular dysfunction, tricuspid valve regurgitation, and baffle related problems may be time dependent, the elapsed time after operation could account for differences between the Mustard and the Senning cohort. Therefore, if significant differences between the two procedures were found, multiple logistic regression analysis was done, adjusting for the type of operation and the length of the postoperative period. Results were reported as odds ratios (OR) and 95% confidence intervals (CI). The level of significance was set at p ⩽ 0.05.



Eighty two of the 339 patients (24.2%) died during the immediate or late postoperative course. Early mortality was observed in 56 patients (16.5%); this corresponded to two thirds of all fatal cases (68.3%). Late mortality was observed in 26 patients (7.7%). Of these patients, 10 died in the first year after the operation, and the remaining 16 either died suddenly (n  =  6) or died from cardiac failure (n  =  3), during a redo procedure (n  =  2), or in one case from cardiac arrest associated with fever and apnoea. In four cases, the cause of death was unknown. The actuarial survival at one, five, 10, 20, and 30 years after operation was 80.8%, 78.4%, 77.7%, 75.1%, and 67.2%, respectively. Excluding early mortality from the survival analysis, the actuarial survival at 10, 20, 25, and 30 years after operation was 91.7%, 88.6%, 87.5%, and 79.3%, respectively.

High variability in early (range 12.5–23.9%) and late mortality (range 2.1–15.2%) could be observed among the different centres. In the 1970s, operations for congenital heart disease in Belgium were predominantly done at four university hospitals, with a varying case load. From 1975 to 1982—the period when most Mustard and Senning operations were undertaken—an average of 2.8 procedures per centre were done annually, ranging from 1.0–6.5 operations a year. However, no direct relation was found between the number of operations done and early mortality.

There was a tendency for better overall (78.6% v 71%) and actuarial survival in patients having the Senning repair compared with the Mustard repair (fig 2). These differences were, however, not significant. In contrast, survival analysis of early survivors according to the type of operation and the complexity of the transposition showed significant differences. Patients having a Senning repair of a simple transposition had very good outcome, with a 20 year survival of 95.7% (fig 3). Patients receiving a Mustard repair of a simple transposition had 10, 20, and 30 year survival rates of 91.4%, 89.4%, and 84.4%, respectively. Actuarial survival of patients receiving Senning and Mustard operations to repair complex transpositions was comparable, with 10, 20, and 25 year survival rates of 84.4%, 84.4%, and 63.3% for Senning patients, and 86.1%, 76.3%, and 76.3% for Mustard patients. Figure 3 shows that the first year after operation is critical in patients with complex transpositions. Mortality in these patients is 9%.

Figure 2

Actuarial survival estimates of 283 patients surviving 30 days after Mustard or Senning operations.

Figure 3

Actuarial survival estimates of 283 patients surviving 30 days after Mustard or Senning operations, with simple or complex transposition of the great arteries.

Current status of survivors

The mean age of the 257 late survivors was 18.2 years (table 2). They were followed for an average of 17.1 years after the Senning or Mustard procedure. The time period between the final examination and the termination of data collection in the respective centres was 0.8 years, indicating that the data accurately reflect the current status of the survivors.

Table 2

Current status of 257 survivors following Mustard or Senning operations

Educational level attained and employment status were investigated in 106 adult survivors (age ⩾ 18 years). About 45% of these patients had received either a college or a university degree or were pursuing a degree. The distribution of the respective levels of education attained was comparable among the Mustard and Senning cohorts. Special education, however, was more prevalent in the Mustard cohort. The relatively young mean age of the Senning cohort implied that most of these patients were still students, in contrast to the Mustard cohort, in which the majority of the individuals were employed.

In 186 patients, the NYHA class assessed during the final examination was noted in the medical record. Overall, 171 patients were assigned to class I, and 15 were assigned to class II, indicating good functional status. In 199 patients, the ability index was deduced using descriptions assessing the physical and social functioning abilities of each patient. In all, 173 patients were leading a normal life (class 1). Twenty four patients were able to work but experienced intermittent symptoms and some interference with life (class 2). Only two patients were unable to work and were limited in all activities (class 3), for extracardiac reasons. The Mustard cohort had significantly fewer class 1 patients and more class 2 patients than the Senning cohort (Fisher’s exact test: 6.993; p  =  0.023).

The frequency and type of sports activity was reported for 163 patients. About half of these patients engaged in sports on a regular basis. However, the majority of the Mustard cohort admitted to engaging in no sporting activity. This differed significantly from the Senning cohort (χ2  =  23.4; df  =  3; p < 0.001). Individuals engaged in sports mostly participated in activities of moderate intensity level.

Arrhythmia-free survival

Actuarial arrhythmia-free survival 10, 15, 20, and 25 years after surgery was 77.7%, 71.1%, 57.6%, and 35.7%, respectively. No significant difference in arrhythmia-free survival was observed between the Mustard and Senning operations (log rank  =  0.09; df  =  1; p  =  0.76). However, according to the complexity of the transposition, significant differences were found (fig 4). Patients receiving Mustard repair of a simple transposition had an arrhythmia-free survival of 86.2% at 10 years, and 70.1% at 20 years after surgery. Senning patient with simple transposition had survival rates of 82.6% and 54.1% at 10 and 20 years after operation, respectively. Arrhythmia-free survival in patients with complex transposition 10 and 20 years after repair was 60% and 35% in Mustard patients, and 64.1% and 45.4% in Senning patients. Although patients with simple transposition were free of arrhythmias for a longer period, there was a pronounced decline 15 years after the atrial switch operation.

Figure 4

Actuarial arrhythmia-free survival in 283 patients surviving for 30 days after Mustard or Senning operations with simple or complex transposition of the great arteries.

Of the 257 late survivors, 21 (8.2%) had a documented episode of atrial flutter. Atrial flutter was significantly more prevalent in the Mustard cohort (20.5%) than in the Senning cohort (1.8%) (χ2  =  26.9; df  =  1; p < 0.001). However, logistic regression showed that atrial flutter was time dependent (OR 1.18, 95% CI 1.05 to 1.33). Pacemaker implantation was reported in 14 patients (5.5%). Indications for pacemaker implantation were sick sinus syndrome (n  =  7), ablation of the Hiss bundle (n  =  1), complete AV block (n  =  1), and unspecified conduction disturbance (n  =  2). For three patients the reason was not documented in the medical records. Antiarrhythmic drugs were prescribed in 11 patients (4.3%).

Systemic ventricular function

Systemic ventricular function was documented in the medical records of 199 patients. Normal function or mild dysfunction was observed in 176 patients (88.4%); moderate or severe dysfunction occurred in 19 (9.5%) and four (2.0%), respectively. The Mustard cohort showed moderate (11.7%) or severe dysfunction (3.3%) more often than the Senning cohort (8.6% and 1.7%). This difference was, however, not significant. Ventricular dysfunction was not influenced by elapsed time after operation (OR 1.05, 95% CI 0.95 to 1.17).

Tricuspid valve regurgitation

Of the 204 patients with reported data on tricuspid valve function, 133 (65.2%) had no or only mild tricuspid regurgitation. Moderate regurgitation was observed in 56 patients (27.5%), while severe regurgitation occurred in 15 (7.4%). Tricuspid valve replacement was done in four patients, and annuloplasty in one.

Severe regurgitation was more prevalent in the Senning cohort (9.2%) than in the Mustard cohort (3.2%); this difference was not significant. Tricuspid valve regurgitation was positively correlated with systemic ventricular function (ρ  =  0.25; p < 0.001).

Baffle related problems

The presence or absence of baffle obstruction was documented in the medical records of 197 patients. Nine patients in the Mustard cohort (15.3%) experienced baffle obstruction, necessitating reintervention. In the Senning cohort, only two patients (1.4%) had baffle obstruction. This difference was significant (χ2  =  14.9; df  =  1; p < 0.001). Adjusting for the elapsed time after the operation, the Mustard operation remained significantly associated with baffle related problems (OR 10.03, 95% CI 1.80 to 55.95).


This is the first multicentre study describing mortality, morbidity, functional status, and aspects of social integration up to 30 years after atrial switch repair for d-TGA. Multicentre follow up studies are often characterised by high attrition because patients are followed by local cardiologists. In this study, the number of patients lost during follow up is very small, because Belgium is a small country with a high population density, easy access to tertiary care, and limited migration of the population. As almost the entire country is covered by the catchment area of the six tertiary care centres, it is assumed that this study covered nearly the entire Belgian population of patients who underwent the Mustard or Senning operation.


In comparison with other published reports, crude mortality rates in this study were relatively high.3,8,9,11 There are two possible explanations for this. The first is publication bias. This study confirmed a high variability in mortality rates among centres, depending on the skills of individual surgeons and the experience of the team caring for the patient in the immediate postoperative period. Single centres with a poor clinical outcome are more reluctant to publish their outcome results than centres that perform well. Second, the relatively low exposure of cardiac surgeons and other health care professionals to these specific operations might have led to a slower learning curve. Although some centres undertook only a few Mustard or Senning operations a year, no direct relation was found with outcome.

Although early mortality was relatively high, late mortality was low and actuarial survival of early survivors was higher than in previous studies,3–5,7,10 both for the overall group and for the Mustard and Senning cohorts separately. Indeed, almost 80% of the early survivors can continue to survive for up to 30 years after the atrial switch operation.

Mortality data from studies comparing the Mustard and Senning operation are contradictory.2,5,10,12 Some studies suggest that survival of patients receiving the Senning operation is better than those receiving the Mustard operation2,8,10—not necessarily because of the operative technique but because patients in the Mustard cohort were operated on at the beginning of the learning curve and without cold cardioplegia for myocardial protection.6 Conversely, data from the only multi-institutional study suggested that short term and intermediate mortality in the Senning cohort was better than in the Mustard cohort mainly in patients with complex transposition.12 In line with the findings of Helbing and colleagues,5 we found that the Senning operation resulted in slightly better survival rates than the Mustard operation, though the difference was not significant. This was true for both crude mortality and actuarial survival rates.


Sustained and non-sustained arrhythmias are common after both the Mustard and the Senning operation. This study showed that almost half the patients experience rhythm or conduction disturbances or required antiarrhythmic treatment during their postoperative course in both groups. Patients with complex transposition had a gradual decrease in arrhythmia-free survival. Conversely, patients with simple transposition seem to be less prone to arrhythmias during the first 15 years after atrial inflow correction. After that time, however, a dramatic decline in arrhythmia-free survival was observed, indicating that arrhythmia occurrence several years after the initial operation is an ongoing process.4 Direct operative trauma to the sinus node or damage to its blood supply have been suggested as the principal causes of rhythm disturbances in both types of operation.4–6

Atrial flutter is an important complication following atrial inflow correction. Ventricular surgery and the use of Dacron baffles, or the presence of residual shunts in patients with complex transpositions, might lead to increased vulnerability to atrial flutter. The incidence of atrial flutter in our Mustard cohort was somewhat higher than in previous reports.2–4,7 As atrial flutter is time dependent,2 this discrepancy probably reflects the longer follow up period in our patients. This could explain the difference in the frequency of atrial flutter between patients who underwent the Mustard operation (20.5%) and those who underwent the Senning operation (1.8%). Although it has been argued that atrial flutter is a risk factor for late sudden death,2 the results from different studies are still contradictory.7 Indeed, while the incidence of atrial flutter in the present study was substantially higher in the Mustard cohort, mortality was comparable with the Senning cohort. Note, however, that the risk of atrial flutter causing sudden death depends on the heart rate, the presence of subobstruction of the venous pathways, and systemic ventricular function.

Ambulatory 24 hour ECG was not done systematically in all patients. Although Holter monitoring is of paramount importance in detecting silent atrial arrhythmias, the predictive value with respect to sudden death is still uncertain.18 Thus other strategies to identify patients at risk for sudden death are required.

Key to the successful long term outcome of the Mustard and Senning operation is the fate of the right ventricle in the systemic circulation.2 Right ventricular function is therefore a major concern in the long term management of this patient population. The incidence of moderate or severe right ventricular dysfunction in our patients was low (11.6%) when compared with the reported incidence of depressed right ventricular function, which ranges from 8%8 to approximately 45%.5 This wide variation reflects the qualitative character of echocardiographic evaluation, the lack of uniform definitions of right ventricular function, the time after the operation, the operative technique used, and the patient population under study. Indeed, the multicentre and retrospective character of this study implies that the evaluation of the right ventricle by paediatric and congenital cardiologists involved in the follow up of Mustard and Senning patients is probably not done in a standardised and uniform way. This hampers the comparability of our results with other published data.

In addition to the 11.6% incidence of ventricular dysfunction in late survivors, patients who died from cardiac failure (n  =  4), who received a heart transplant (n  =  2), and who underwent arterial switch operation (n  =  2) should also be considered as having ventricular dysfunction. Although the number of patients with systemic right ventricle dysfunction is likely to increase steadily over the coming years,6 our study confirmed previous findings that the right ventricle is capable of performing as the systemic pumping chamber for at least three decades.7

Physical and social functioning

Most long term survivors of the Mustard or Senning operation are in good clinical condition. They display satisfactory functional status and social integration, as indicated by educational level attained, employment status, participation in sports activities, NYHA classification, and ability index. This may contribute to the patients’ quality of life.

The high prevalence of learning difficulties in the Mustard cohort may reflect neurological deficits resulting from an extended period of hypoxaemia during infancy. Undertaking the Senning operation at an earlier age, along with simultaneous prostaglandin E treatment, may have decreased these neurological deficits, which in turn would have improved learning and academic performance.

With respect to functional status, patients who had the Senning operation were superior to those having the Mustard procedure. More patients in the Mustard group were unable to work, experienced some interference with their life, and had intermittent symptoms. The higher level of participation in sports activities by the Senning cohort could partly be explained by sports at school in this younger group of patients. With respect to the physical functioning, formal exercise testing data would be very valuable in this patient population. Therefore, this retrospective survey should be expanded to include a prospective study assessing exercise performance, as well as a quantitative evaluation of ventricular function and tricuspid valve competence.

Methodological issues

The retrospective design of our study necessitated a review of the patients’ medical records. Because some variables used in the study were not documented in all cases, missing values were inevitable. In addition, variables were not followed up longitudinally, implying that assessment of determinants of mortality or morbidity using multivariate statistics was not feasible.

A major advantage of multicentre studies is that they yield more generalisable results. However, the heterogeneity of the data and the data collection, based on existing medical records, was an important methodological concern. Examples of such heterogeneity were the definitions of arrhythmias used by the various cardiologists, and the assessment of right ventricular function. Sometimes the exact date of an event or treatment was not known, but only the year was available. In these cases, the most conservative estimation was made by using the first day of that year (1 January) in the survival analysis.


In this study we assessed the long term outcome of patients who underwent a Mustard or Senning operation for transposition of the great arteries. Although early mortality in this study was relatively high, long term results were favourable in terms of late mortality, morbidity, functional status, and social integration. While the Senning operation was not superior to the Mustard operation in terms of mortality, Senning patients did show a higher educational level, better functional status, more engagement in sports activities, and fewer baffle obstructions. Other differences between patients receiving either Mustard or Senning repair operations could be explained by the longer postoperative course in the Mustard cohort. Arrhythmia-free survival was better in patients with simple transposition than in complex transposition. This study confirmed a high variability of mortality among different centres, indicating the limited generalisability of single centre experiences.


This study was supported by the Belgian National Foundation for Research in Paediatric Cardiology.


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  • * Also Division of Congenital Cardiology, University Hospitals of Leuven, and Belgian National Foundation for Research in Paediatric Cardiology

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