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Summary of recommendations on percutaneous coronary intervention for the reperfusion of acute ST elevation myocardial infarction
  1. G Montalescot1,
  2. H R Andersen2,
  3. D Antoniucci3,
  4. A Betriu4,
  5. M J de Boer5,
  6. L Grip6,
  7. F J Neumann7,
  8. M T Rothman8
  1. 1Centre Hospitalier Universitaire Pitié-Salpétrière, Paris, France
  2. 2Skejby University Hospital, Aarhus, Denmark
  3. 3Ospedale Careggi, Firenze, Italy
  4. 4Hospital Clinico, Barcelona, Spain
  5. 5Isala Klinieken, Zwolle, The Netherlands
  6. 6Sahlgrenska University Hospital, Göteborg, Sweden
  7. 7Herzzentrum Bad Krozingen, Bad Krozingen, Germany
  8. 8The London Chest Hospital, London, UK
  1. Correspondence to:
    Dr G Montalescot
    Institut de Cardiologie, Bureau 2-236, Centre Hospitalier Universitaire Pitié-Salpétrière, 47 Bl de l’Hôpital, 75013 Paris, France; gilles.montalescotpsl.ap-hop-paris.fr

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Since primary percutaneous coronary intervention (PCI) is the mainstay of reperfusion in acute myocardial infarction (AMI), and because AMI represents the most urgent situation for PCI, recommendations based on scientific evidence and expert experience would be useful for centres practising primary PCI or those looking to set up a primary PCI programme. With this in mind, a group of eight European interventional cardiologists (all based at high volume centres) formed an expert consensus to provide recommendations on this subject.

The recommendations are intended for specialists who possess the necessary knowledge, experience, and skills to perform PCI, and who work in environments with appropriate resources and facilities.

RECOMMENDATIONS FOR PCI IN AMI

When performed by experienced operators, we strongly recommend PCI as the reperfusion strategy of choice for patients with AMI. When thrombolysis is contraindicated or has failed, or when patients are in cardiogenic shock, rapid transfer to a secondary unit should be ensured. Studies have shown that, where facilities are available, most AMI patients are candidates for PCI,1 and that PCI is effective in re-establishing coronary artery perfusion and in providing a good outcome in both the short and long term.2

We strongly recommend that PCI for AMI is performed swiftly, with a door-to-balloon time of < 2 hours. The benefit of reperfusion with primary PCI is maximal within two hours of symptom onset, but appears to be present in a time window of 12 hours between onset of chest pain and PCI.2,3 Mortality is also linked to door-to-balloon time, with a significant increase in mortality when times exceed two hours.3 We would therefore strongly recommend the transfer of AMI patients to cardiac catheterisation laboratories if the expected time to arrival is likely to be ⩽ 2 hours. If the time to catheterisation is likely to exceed three hours, thrombolysis should be regarded as a valid option. If a patient undergoing thrombolytic therapy does not have signs of reperfusion 90 minutes after starting the therapy, transfer for rescue PCI should be considered. A number of studies and a recent meta-analysis have demonstrated the feasibility and benefit of transferring patients to units with cardiac catheterisation facilities.4

PCI should ideally be performed in high volume centres (> 33 primary PCI procedures per year) with fully equipped interventional laboratories and experienced support staff.1

Considering the high risks associated with many of these urgent procedures, we recommend that a complete, well trained team of nurses and, wherever possible, two physicians should be present in the catheterisation laboratory throughout the procedure (one senior interventionalist for the PCI procedure and one physician to monitor the patients’ haemodynamic, respiratory and, if necessary, anaesthetic state).1 Many centres use only one physician; a single physician, however, cannot manage the most difficult cases involving cardiac arrest, cardiogenic shock, and a need for intubation with complete safety. Good outcomes can be achieved in hospitals without cardiac surgery support given successful completion of a PCI training programme and appropriate selection of cases.5 A broad range of catheters, guidewires, stents, and supportive devices such as intra-aortic balloon pumps (IABP) should also be available in these hospitals.

There is clear evidence and guidelines stating that PCI for AMI should be performed in high volume centres (400 PCI cases per year in total).1 However, the C-PORT study showed that after selection of cases, patients who are out of range of high volume centres could be successfully treated in low volume centres with well trained teams.5

We strongly recommend the use of stents for AMI and the use of direct stenting whenever possible. IABPs should be available and their use is strongly recommended in patients with AMI complicated by cardiogenic shock. Radial access is a good alternative to the femoral approach but only in centres already routinely using this approach for elective cases. We do not recommend the systematic use of closure devices in AMI patients. Although promising, the use of thrombectomy and distal protection devices carry the risk of dislodging a thrombus during delivery.

Our recommendations for the use of pharmacological treatments are outlined below. The use of aspirin in reducing ischaemic complications after coronary angioplasty is widely accepted1 and therefore aspirin should be given as early as possible, with a recommended starting dose > 160 mg; intravenous administration is preferable.

Whenever possible, a loading dose of 300–600 mg clopidogrel is recommended before intervention and a daily dose of at least 75 mg clopidogrel for at least one month post-intervention.

To date, abciximab is the only glycoprotein IIb/IIIa inhibitor proven to be clinically effective in PCI for AMI.6–10 Trials, including RAPPORT, ISAR-2, ADMIRAL, CADILLAC, and ACE, have demonstrated the efficacy of abciximab during PCI for AMI. All five trials testing abciximab in primary angioplasty showed significant reductions in ischaemic events at 30 days. Therefore, immediate administration of abciximab on first presentation is recommended for AMI patients scheduled for primary PCI.

We recommend the administration of heparin at a dose adjusted to weight and/or activated clotting time (ACT). We recommend 70 U of unfractionated heparin (UFH) per kilogram in patients undergoing PCI with adjuvant glycoprotein IIb/IIIa inhibitors. Higher doses of UFH used together with glycoprotein IIb/IIIa inhibitors are associated with a risk of over-anticoagulation. Substitution of low molecular weight heparin for UFH appears promising but firm recommendations cannot be given at this time.

The American College of Cardiology recommends that patients not receiving glycoprotein IIb/IIIa inhibitors should be given sufficient UFH during coronary angioplasty to achieve an ACT of 250–300 s and 300–350 s. The UFH bolus should be reduced when glycoprotein IIb/IIIa inhibitors are given to achieve a target ACT of 200 s.1

CONCLUSION

This is the first paper to draw together a full range of recommendations for PCI in AMI including timing, adjunctive pharmacological therapies and length of hospital stay post-PCI. More detailed analysis of the evidence supporting these recommendations can be found in the electronic version of this paper.

Table 1

Recommendations for specific cases and post-PCI

Acknowledgments

This European Expert Consensus was supported by an unrestricted educational grant from Eli Lilly and Company.

REFERENCES

View Abstract
  • Detailed Recommendations

    Detailed analysis of the evidence supporting the recommendations on percutaneous coronary intervention for the reperfusion of acute ST elevation myocardial infarction is available.
    [View Detailed Recommentations]

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