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Lung water content is not increased in chronic cardiac failure
  1. C S O’Dochartaigh1,
  2. B Kelly2,
  3. M S Riley3,
  4. D P Nicholls1
  1. 1Department of Medicine, Royal Victoria Hospital, Belfast, UK
  2. 2Department of Radiology, Royal Victoria Hospital, Belfast, UK
  3. 3Department of Respiratory Medicine, City Hospital, Belfast, UK
  1. Correspondence to:
    Professor Paul Nicholls
    Royal Victoria Hospital, Belfast BT12 6BA, UK; paul.nichollsroyalhospitals.n-i.nhs.uk

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In patients with acute heart failure, lung water content is increased leading to pulmonary oedema.1 This can be detected clinically and radiologically, and makes a major contribution to the severe dyspnoea characteristic of this condition. In contrast, the lung water content in stable chronic cardiac failure has not been defined, as previous studies all included patients with overt fluid overload in their analysis.2–4 We therefore carried out a pilot study with computed tomography (CT) measurement of lung water in patients with stable chronic cardiac failure, as well as some patients with acute heart failure, and compared their scans with scans from patients without evidence of heart failure.

METHODS

Seventeen patients with chronic cardiac failure (three women) took part in this study. The mean age was 60.4 years (range 41–79 years), mean height 1.73 m (1.58–1.97 m), and mean weight 83.3 kg (64–103 kg). Three were current smokers and four had never smoked. The cause of the heart failure was ischaemic heart disease (10 patients) or dilated cardiomyopathy (seven). All had at least one previous episode of pulmonary oedema and a mean left ventricular ejection fraction of 27% (range 15–40%) measured by echocardiography in nine and by gated blood pool scanning in eight. At the time of the study the patients had been stable with treatment for at least six weeks and were in New York Heart Association (NYHA) functional class II (n  =  9) or III (n  =  8). Patients with lung disease were excluded on clinical and radiological grounds. Treatment consisted of a loop diuretic (mean dose of furosemide or its equivalent 49 mg daily) in 15, an angiotensin converting enzyme inhibitor in all, a β adrenoceptor antagonist in eight, and digoxin in nine. On the day of testing, none had fluid overload on clinical or radiological examination. Dyspnoea was assessed by NYHA class and by their peak achieved oxygen consumption on treadmill exercise testing. We also studied four men aged 62–73 years with severe symptomatic heart failure (NYHA IV). All had clinical evidence of fluid overload on the day of examination (see above) but were able to tolerate lying flat for five minutes in the scanner. Exercise testing was not carried out in this group. All patients gave written informed consent for the scan. The protocol had been approved by the local ethics committee.

Control scans were taken from patients attending the radiology department for non-cardiac reasons, who had undergone CT without contrast enhancement. Eight of the 11 were women and the mean age was 46.5 years (range 16–77 years). Four were current smokers. Exercise test results were available for four (table 1). The reasons for scanning were possible metastases from non-lung cancer primary tumours (three); lymphoma treatment follow up (two), and one each of pneumothorax, myeloproliferative disorder, abdominal mass, mediastinal mass, diaphragmatic nodule, and resolved lobar pneumonia. Scans were recorded by a Somatom Plus-S spiral CT scanner (Siemens AG, Erlangen, Germany). Exposures were taken during one second of apnoea at full inspiration at 120 kV and 315 mA. The total radiation dose for each scan was about 5 mSv. After a frontal scan of the chest was obtained, two 10 mm slices were selected, one at the level of the carina and one 2 cm above the dome of the right hemidiaphragm. Images were analysed on the host computer (MicroVAX II/3200) with manufacturer’s software (SOMARIS system). The region of interest was defined by tracing the lung field borders on the computer screen. The appropriate scale range was then set (−1000 to −500 Hounsfield units (HU) for air predominant tissue, −500 to −100 HU for water predominant tissue, and −100 to +3071 HU for solid tissue). The lung water content (percentage) was defined as the area (cm2) of water predominant lung ÷ area of air predominant lung (water to air ratio).

Table 1

 Lung water content (LWC) and exercise capacity (peak achieved oxygen uptake (PVo2)) in heart failure

Two investigators performed the procedure above jointly for the first nine scans to ensure consistency of interpretation (CO’D, BK). The same observer then analysed the same test on three separate occasions, in random order, from multiple slices to establish a coefficient of variation for within-observer, within-test repeatability. Between-test repeatability could not be tested, as this would have required repeated scans. Values are given as mean (SD) and were compared by Student’s t test. A p < 0.05 was accepted as significant. Data from the acute heart failure group were not entered into the analysis in view of the small numbers involved but are included in table 1 to allow comparison.

RESULTS

The coefficient of variation for estimation of lung water content was acceptable at 6.6%. There was no significant difference in lung water content between controls and patients with NYHA II–III chronic cardiac failure, despite a major difference in peak oxygen consumption (table 1). As expected, those patients with severe chronic cardiac failure and evidence of fluid overload had a much higher lung water content.

DISCUSSION

In a previous study, the lung water content on CT was increased in patients with evidence of pulmonary venous congestion,2 but in those without such evidence, increased lung density was observed in the posterior parts of the lungs only. Increased extravascular lung water has also been shown in chronic cardiac failure but many of the patients in these studies had clinical evidence of fluid overload at the time of study.3,4 Despite this limited database, many clinicians continue to believe that dyspnoea in patients with chronic cardiac failure is mainly caused by an increase in lung water content.

We chose CT for the present study because of its convenience and availability. Ethical issues associated with the use of such tests in patients in whom there is no clinical indication for scanning resulted in the small number of patients studied. CT, while non-invasive, is a semiquantitative technique, which measures density and assumes that the zone −500 to −100 HU is due to water, mainly because water is used as a calibrator. Furthermore, it does not permit the distinction of intravascular and extravascular water. Nevertheless, data from this pilot study were sufficient to suggest that lung water content does not increase greatly in patients with stable chronic cardiac failure, and so changes in lung water content are unlikely to contribute to the exertional dyspnoea characteristic of this condition.5

Acknowledgments

We are grateful to Ms A Martin for assistance during the scanning and to Dr M Stevenson for statistical advice.

REFERENCES

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