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The changing face of acute myocardial infarction
  1. N Danchin
  1. Correspondence to:
    Professor Nicolas Danchin
    Hôpital Européen Georges Pompidou, Paris, Service de Cardiologie, HEGP, 20 rue Leblanc, 75015 Paris, France; nicolas.danchinegp.ap-hop-paris.fr

Abstract

The appointment of new cardiologists and their involvement in emergency care may lead to decreased mortality in patients suffering acute myocardial infarction

  • acute myocardial infarction

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Over the past 15 years, clinical researchers have documented the efficacy of both new (or older) medications and percutaneous interventions in patients with acute myocardial infarction. An integrated approach, mixing the use of pharmacologic agents and interventional procedures, has been promoted, with the hope of reducing early (and late) mortality. However, translating recommendations into the “real world” of everyday clinical practice is a difficult exercise and obviously has more chances of success when the educational efforts are, at least initially, directed to a more limited number of physicians, namely, specialists in the target field.

In this regard, the paper by Murphy and colleagues1 provides interesting data by investigating the evolution of early mortality of acute myocardial infarction, 10 years apart (from the late 1980s to the late 1990s), in Scotland, and this in relation to the appointment of new cardiologists involved in emergency care. All acute hospitals in Scotland participated in the study. Overall, median 30 day mortality decreased by an absolute 2.4% (or a 12% relative decrease), a difference highly significant after multivariate adjustment for potential confounders. Importantly, between-hospital variations decreased considerably from the first to the second period (difference between highest and lowest survival: 13.0% in period 1 v 7.6% in period 2). Likewise, nine of 26 hospitals in the 1988–1991 period but only two in the 1998–2001 period had an adjusted risk of death significantly higher than average. These results therefore document the improved, but also more homogeneous, results achieved in the management of patients with acute myocardial infarction in Scotland over a relatively short period of time. As, from period 1 to period 2, at least one cardiologist has been appointed in each Scottish hospital, the authors suggest that both the decrease in mortality and the lower between-hospital variation may be related to the appointment of new cardiologists and their involvement in emergency care.

APPOINTMENT OF NEW CARDIOLOGISTS

Indeed this suggestion seems logical: the appointment of new cardiologists is likely to result in both improved and more rapid diagnosis of cardiac conditions such as myocardial infarction, and also a more appropriate application of guidelines and recommendations. In a recent survey that we carried out in a large sample of French general practitioners, consultation with a cardiologist in the preceding year was an independent determinant of more adequate implementation of guidelines and better risk factor control in patients with chronic coronary artery disease or at high cardiovascular risk (personal data on file).

However, the data provided in the study cannot demonstrate that the appointment of more cardiologists is the sole explanation for improved outcomes: once myocardial infarction has been recognised, what becomes crucial is the immediate use of appropriate treatments. In other words, appointing a cardiologist specialised in emergency care will have a positive impact only as long as the cardiologist will be reasonably competent and will conform to the most recent recommendations.

In this regard, the reader would definitely have liked to know what changes were observed in the actual management of the patients from the late 1980s to the late 1990s and early 2000s. During this period of time, emphasis has been put both on the importance of reperfusion therapy and on the use of concomitant medications such as angiotensin converting enzyme (ACE) inhibitors. As regards reperfusion therapy, the result of ISIS-2 (second international study of infarct survival), demonstrating the synergistic action of aspirin and thrombolysis, were published in 1998.2 It is therefore unlikely that the recommendations derived from this trial would have been widely applied before 1990 (that is, during the first half of the reference period). In addition, direct angioplasty was not used during the whole duration of the first period. The studies documenting the superiority of primary angioplasty over intravenous thrombolysis, and the major role of time delay on the efficacy of thrombolysis, were published much later.3,4 Similarly, the positive role of early ACE inhibition was documented after the end of the reference period.5 Consequently, major changes in the management of acute myocardial infarction are likely to have occurred from period 1 to period 2, and this not only because new cardiologists were appointed, but above all because medical knowledge progressed during that time. In the French experience, important changes in the early management of patients with acute myocardial infarction have been observed between 1995 and 2000, and this in spite of the fact that similar numbers of cardiologists were involved in acute cardiac care between the two surveys.5,6 These changes resulted in a significant decrease in early mortality.7

TIME DELAY FROM SYMPTOM ONSET

Finally, another major aspect of the management of myocardial infarction is the time delay from symptom onset to delivery of appropriate care, particularly reperfusion therapy. Here again, one would have liked to know whether time to hospital admission (and/or time to first medical contact) had varied in Scotland between the two study periods. In this respect, the French experience is particularly disappointing with, if anything, longer time delays in 2000 than in 1995.8

Overall improvement in early outcomes certainly has several explanations; improved scientific knowledge leading to more appropriate medical care is central. As suggested by Murphy and colleagues,1 implementation of guidelines by more specialised medical personnel is also important. In the specific case of acute myocardial infarction, however, where every single minute matters, one cannot hope for much further improvement in outcomes in the absence of adequate, public oriented information in order to shorten the duration of acute myocardial ischaemia. And this may well be the most difficult task cardiologists will be confronted with in the next decade.

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