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Evaluation of survival and ischaemic and thromboembolic event rates in patients with non-valvar atrial fibrillation in the general population when treated and untreated with warfarin
  1. C J Currie1,
  2. M Jones2,
  3. J Goodfellow3,
  4. P McEwan2,
  5. C L Morgan1,
  6. C Emmas4,
  7. J R Peters5
  1. 1School of Medicine, Cardiff University, Cardiff, UK
  2. 2School of Mathematics, Cardiff University, Cardiff, UK
  3. 3Wales Heart Research Institute, Cardiff University, Cardiff, UK
  4. 4Outcomes Research AstraZeneca UK Ltd, Luton, UK
  5. 5Department of Medicine, University Hospital of Wales, Cardiff, UK
  1. Correspondence to:
    Dr Craig Currie
    Cardiff Research Consortium, Heath Park, Cardiff CF14 4UJ, UK; curriec{at}cardiff.ac.uk

Abstract

Objective: To compare survival and adverse outcome of patients with non-valvar atrial fibrillation (NVAF) treated with or without warfarin.

Design: Record linkage method to identify patients with a previous hospital diagnosis of atrial fibrillation and to link these patients to international normalised ratio (INR) test results and mortality data.

Setting: Cardiff and the Vale of Glamorgan, Wales.

Main outcome measures: Mortality, specifically from ischaemic and thromboembolic events.

Results: 6108 patients were identified with NVAF, of whom 36.4% received warfarin. Mean survival in the warfarin and non-warfarin groups was 52.0 months and 38.2 months, respectively (p < 0.001), and 14.4 months (p < 0.001) after adjustment for confounding factors. Warfarin treated patients in the upper quartile of INR control had significantly longer survival (57.5 months) than did those in the lowest quartile of control (38.1 months, p < 0.001). The risk of stroke in the warfarin group when treated was lower than that in the non-warfarin group (relative rate (RR) 0.74, p < 0.001). The risk of death from ischaemic stroke was lower in the warfarin group (RR 0.43, p < 0.001). The risk of all ischaemic and embolic events in the warfarin group was lower when they were taking warfarin (RR 0.74, p < 0.001). The risk of bleeding in the warfarin group when treated was greater (RR 1.78, p  =  0.001).

Conclusions: Patients with NVAF within the recommended target INR range of 2.0–3.0 survive longer and have reduced morbidity. Probably too few people are anticoagulated with warfarin in NVAF.

  • AF, atrial fibrillation
  • ICD-10, International classification of diseases, 10th revision
  • INR, international normalised ratio
  • NVAF, non-valvar atrial fibrillation
  • RR, relative rate
  • atrial fibrillation
  • warfarin
  • anticoagulation
  • stroke

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Footnotes

  • Published Online First 12 May 2005

  • The study was funded by AstraZeneca (UK), which developed a product that will compete directly with warfarin for some indications including non-valvar atrial fibrillation. Their input was minimal, although they reviewed an almost finalised manuscript and made acceptable presentational changes.

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