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End points in clinical trials: are they moving the goalposts?
  1. D Y Leung,
  2. J K French
  1. Cardiology Department and South West Sydney Clinical School (UNSW), Liverpool Hospital, Elizabeth Street, Liverpool, NSW 2170, Australia
  1. Correspondence to:
    Professor John K French
    Department of Cardiology, Liverpool Hospital, Elizabeth Street, Liverpool, NSW 2170, Australia; j.french{at}unsw.edu.au

Abstract

In selecting and defining composite end points in clinical trials, are we trading off clinical significance for statistical significance?

  • CABG, coronary artery bypass graft surgery
  • CK, creatine kinase
  • MI, myocardial infarction
  • PCI, percutaneous coronary intervention
  • clinical trials
  • coronary heart disease
  • end points

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