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The role of vasodilators in the prevention and treatment of no-reflow following percutaneous coronary intervention
  1. S A Harding
  1. Correspondence to:
    Dr Scott Harding
    Department of Cardiology, Wellington Hospital, Private Bag 7902, Wellington, New Zealand; scott.harding{at}ccdhb.org.nz

Abstract

The routine use of vasodilators in patients with acute coronary syndromes or other groups undergoing percutaneous coronary intervention (PCI) cannot be recommended at present. However, in the event of no-reflow occurring following PCI, intracoronary adenosine or verapamil should be administered

  • AMISTAD, Acute Myocardial Infarction STudy of Adenosine
  • PCI, percutaneous coronary intervention
  • SVG, saphenous vein graft
  • TIMI, Thrombolysis in Myocardial Infarction
  • no-reflow
  • vasodilators
  • adenosine
  • verapamil

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No-reflow has been variably defined. In the setting of percutaneous coronary intervention (PCI) it is best defined as inadequate myocardial perfusion in the target vessel territory without evidence of mechanical epicardial vessel obstruction. Angiographic no-reflow defined as less than Thrombolysis in Myocardial Infarction (TIMI) 3 flow occurs in 2% of all PCIs.1 Angiographic no-reflow is associated with an increased incidence of death, myocardial infarction and heart failure.2 More recently it has become evident that there is frequently persistent microcirculatory impairment and abnormal tissue level perfusion following PCI despite the presence of TIMI 3 flow (normal epicardial flow).3 Microvascular dysfunction is thought to account for 50–70% of all periprocedural myocyte injury and occurs most frequently in the setting of PCI for acute myocardial infarction or degenerative saphenous vein grafts (SVGs).4

Use of a vasodilator to treat no-reflow was first described by Wilson et al in 1989 who reported a favourable response to papaverine in a single patient.5 Since this time the effect of several different vasodilators on no-reflow has been investigated. To understand the potential role and limitations of vasodilators in preventing no-reflow and periprocedural myocyte injury it is necessary to understand the underlying pathogenesis.

PATHOGENESIS OF NO-REFLOW AND IMPLICATIONS FOR THERAPEUTIC INTERVENTION

The pathogenesis of the microvascular dysfunction leading to no-reflow is complex. Microvascular spasm, distal embolisation of atheroma and thrombus, microvascular plugging by platelets and leucocytes, endothelial swelling, tissue oedema compressing the microvasculature, oxidative stress and inflammation may all play a role.4 The multiple underlying mechanisms contributing to the development of no-reflow make it likely that a single therapeutic strategy will be only partially effective in preventing or treating no-reflow. It also important to understand that mechanisms involved in the pathogenesis of no-reflow may vary depending on the clinical scenario. For example, in the setting of acute myocardial infarction, disruption of the microvasculature and the surrounding tissues due to prolonged ischaemia along with reperfusion injury play a prominent role whereas in SVG interventions distal atheroembolism is the predominant mechanism.

This variation in the underlying pathophysiology raises the possibility that a therapeutic strategy successful in one clinical scenario may not necessarily be effective in others. Experience from previous clinical trials suggests that this is the case. For example, distal embolisation protection devices have been shown to preserve microvascular function and reduce myocyte injury during SVG interventions but not in those undergoing primary PCI.6 In contrast, the use of glycoprotein IIb/IIIa antagonists in patients with acute coronary syndromes has been shown to preserve microvascular function, reduce periprocedural myocyte injury and improve clinical outcomes, while their use in patients undergoing SVG intervention has not been associated with significant benefit.3 Thus, while there are reasons to expect that vasodilators may be beneficial in treating no-reflow, their efficacy may vary in differing clinical situations and the optimal approach to preventing microvascular dysfunction will involve targeting multiple mechanisms.

USE OF VASODILATORS IN NO-REFLOW: CURRENT KNOWLEDGE

The periprocedural use of several different vasodilators for the prevention or treatment of no-reflow has been investigated in a number of observational studies and randomised trials1,7,8,9,10,11,12,13,14 These studies have varied widely in the patient group studied, methodology (drug, dose, route and frequency of administration) and the outcome measures used. Verapamil1,7,8,9,10 and adenosine11–14 have been the vasodilators most frequently studied. Both these agents may improve myocardial perfusion by relieving small vessel spasm, but they also have additional effects which may reduce reperfusion injury. Verapamil has been shown to improve calcium haemostasis in ischaemic myocardial cells, while adenosine has been shown to reduce neutrophil activation and endothelial injury.3

The studies investigating the use of verapamil to treat angiographic no-reflow following PCI to date have been small and have suggested that use of verapamil leads to an improvement in no-reflow as measured by TIMI flow rates and frame counts in the target vessel.1,7 Several small studies have also suggested that routine administration of intracoronary verapamil at the time of PCI prevents microvascular dysfunction following intervention in acute myocardial infarction or on saphenous vein grafts.8,9,10 Almost all the studies with adenosine to date have examined whether routine administration reduces no-reflow following PCI in the setting of acute myocardial infarction. Again several small studies have suggested that adenosine improves microvascular function and reduces infarct size.11–13 However, the AMISTAD II study,14 by far the largest study, enrolling 2118 patients with anterior ST elevation myocardial infarctions treated with either thrombolysis (60%) or primary PCI (40%), failed to demonstrate a reduction in the composite primary end point of death, new congestive heart failure or the first re-hospitalisation for congestive heart failure. There was a trend toward a reduction in the secondary end point of infarct size but this did not reach statistical significance.

In this issue of Heart Vijayalakshmi and colleagues15 report the results of a randomised comparison of intracoronary adenosine, verapamil or placebo in a mixed population containing both those with ST elevation and non-ST elevation acute coronary syndromes. This is the first trial to compare directly the effects of these vasodilators in an acute coronary syndrome population. Consistent with previous studies their results suggest that both verapamil and adenosine improved coronary blood flow in the target vessel and were associated with an improvement in wall motion index. Both drugs had similar benefits but verapamil was associated with hypotension and complete heart block lasting up to three hours in 18% of the cases. The significance of these results should be interpreted with some caution. Although the improvements in TIMI frame counts and wall motion index were statistically significant, the size of the effect was relatively small and may not be of clinical significance.

LIMITATIONS OF AVAILABLE STUDIES AND REMAINING QUESTIONS

Although the study by Vijayalakshmi et al15 adds to our knowledge by providing further information about the comparative safety and efficacy of adenosine and verapamil, there remains a number of important unresolved issues. The optimal dose, route, frequency and duration of administration for these agents are unknown. For verapamil intracoronary administration of doses between 50–1000 μg have been used.7,10 A dose of around 500 μg has been the most commonly used and seems effective in improving microvascular flow but is associated with a risk of transient heart block. For adenosine intracoronary boluses between 24 μg and 4 mg have been used in some studies11,12 while others have used intravenous infusions at rates of 10–70 μg/kg/min.13,14 A subgroup analysis of the AMISTAD II trial14 suggested that a higher infusion rate of 70 μg/kg/min may be more effective. Unfortunately there are no studies comparing the relative efficacy of a prolonged intravenous infusion compared to a single or multiple intracoronary boluses.

It remains uncertain whether the use of vasodilators such as adenosine or verapamil to prevent or treat no-reflow reduces important clinical end points such as death or heart failure. As discussed previously the majority of studies have demonstrated improvements in a number of surrogate end points such as TIMI flow rate, TIMI frame count and wall motion scores. However, previous experience has taught us that there is frequently discordance between the results of trials using surrogate and clinical end points. This again proved to be the case with AMISTAD II,14 the only clinical trial adequately powered to demonstrate a difference in clinical outcomes failing to do so. Nevertheless, subgroup analysis did demonstrate a reduction in infarct size with the high dose adenosine infusion (70 μg/kg/min). This result was consistent with the findings of the AMISTAD I trial16 in which use of a 70 μg/kg/min adenosine infusion in patients with ST elevation myocardial infarction treated with thrombolysis was also associated with a significant reduction in infarct size. Thus, it is possible that a 70 μg/kg/min infusion may improve clinical outcomes, but this hypothesis needs to be confirmed by an adequately powered clinical trail.

OPTIMAL TREATMENT TO REDUCE NO-REFLOW AND PERIPROCEDURAL MYOCYTE DAMAGE

Given the complex and variable pathogenesis of no-reflow and periprocedural myocyte injury, multiple mechanisms need to be targeted with treatment being tailored to the clinical situation. Treatment with aspirin, clopidogrel, and statins before PCI reduce periprocedural myocyte damage and should be prescribed where possible. Use of glycoprotein IIb/IIIa antagonists in acute coronary syndrome interventions and distal embolisation protection devices in SVG interventions provide additional microvascular protection and improve clinical outcomes. It is difficult to recommend the routine use of adenosine or other vasodilators to prevent no-reflow in acute coronary syndrome patients or other groups undergoing PCI based on the currently available evidence. Further large randomised controlled trials are required to resolve this issue. Should no-reflow occur following PCI, treatment with intracoronary adenosine or verapamil should be administered as this therapy is inexpensive, safe, improves flow in the target vessel and may reduce infarct size.

REFERENCES

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Footnotes

  • Published Online First 10 April 2006

  • Conflict of interest statement: There are no conflicts of interest to declare.

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