Article Text

PDF
Epidemiology
Socioeconomic status, pathogen burden and cardiovascular disease risk
  1. A Steptoe1,
  2. A Shamaei-Tousi2,
  3. Å Gylfe3,
  4. B Henderson2,
  5. S Bergström3,
  6. M Marmot1
  1. 1
    Department of Epidemiology and Public Health, University College London, London, UK
  2. 2
    Division of Microbial Diseases, Eastman Dental Institute, University College London, London, UK
  3. 3
    Department of Molecular Biology, Umeå University, Umeå, Sweden
  1. Professor Andrew Steptoe, Department of Epidemiology and Public Health, University College London, 1–19 Torrington Place, London WC1E 6BT, UK; a.steptoe{at}ucl.ac.uk

Abstract

Objective: Socioeconomic status (SES) is inversely associated with coronary heart disease (CHD) risk. Cumulative pathogen burden may also predict future CHD. The hypothesis was tested that lower SES is associated with a greater pathogen burden, and that pathogen burden accounts in part for SES differences in cardiovascular risk factors.

Methods: This was a cross-sectional observational study involving the clinical examination of 451 men and women aged 51–72 without CHD, recruited from the Whitehall II epidemiological cohort. SES was defined by grade of employment, and pathogen burden by summing positive serostatus for Chlamydia pneumoniae, cytomegalovirus and herpes simplex virus 1. Cardiovascular risk factors were also assessed.

Results: Pathogen burden averaged 1.94 (SD) 0.93 in the lower grade group, compared with 1.64 (0.97) and 1.64 (0.93) in the intermediate and higher grade groups (p = 0.011). Pathogen burden was associated with a higher body mass index, waist/hip ratio, blood pressure and incidence of diabetes. There were SES differences in waist/hip ratio, high-density lipoprotein-cholesterol, fasting glucose, glycated haemoglobin, lung function, smoking and diabetes. The SES gradient in these cardiovascular risk factors was unchanged when pathogen burden was taken into account statistically.

Conclusions: Although serological signs of infection with common pathogens are more frequent in lower SES groups, their distribution across the social gradient does not match the linear increases in CHD risk present across higher, intermediate and lower SES groups. Additionally, pathogen burden does not appear to mediate SES differences in cardiovascular risk profiles.

Statistics from Altmetric.com

Footnotes

  • Funding: This research was supported by the British Heart Foundation and the Medical Research Council, UK. Västerbotten county council provided financial support for Dr Gylfe. The funding source has not been involved in the submission of the manuscript or in the decision to publish the data.

  • Competing interests: None.

  • Abbreviations:
    AU
    arbitrary unit
    BMI
    body mass index
    BP
    blood pressure
    CHD
    coronary heart disease
    CMV
    cytomegalovirus
    FEV1
    forced expiratory volume in 1 s
    HbA1c
    glycated haemoglobin
    HDL
    high-density lipoprotein
    HSV-1
    herpes simplex virus 1
    IgG
    immunoglobulin G
    SES
    socioeconomic status

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.