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Heart rate and microinflammation in men: a relevant atherothrombotic link
  1. O Rogowski1,
  2. I Shapira1,
  3. A Shirom2,
  4. S Melamed3,
  5. S Toker2,
  6. S Berliner4
  1. 1Department of Medicine “D” and Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
  2. 2Faculty of Management, Tel Aviv University, Tel Aviv, Israel
  3. 3National Institute of Occupational & Environmental Health, Raanana, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  4. 4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  1. Correspondence to:
    Professor S Berliner
    Medicine “D”, Tel Aviv Sourasky Medical Center, 6 Weizman Str, Tel Aviv 64239, Israel; shapiraiz{at}tasmc.health.gov.il

Abstract

Objective and background: To explore the possibility that increased resting heart rate (HR) is associated with a microinflammatory response. Such an association could explain, at least in part, the recently described worse cardiovascular prognosis in individuals with increased HR.

Methods: Concentrations of fibrinogen and high-sensitivity C-reactive protein, as well as the absolute number of polymorphonuclear leucocytes, were analysed in a cohort of 4553 apparently healthy men and in those with atherothrombotic risk factors.

Results: Following adjustment for age and body mass index, lipid profile and cardiovascular risk factors, a significant (p<0.001) difference was noted between individuals in the first quintile of HR (⩽58 beats/min) and those in the fifth quintile (⩾79 beats/min) regarding all the above-mentioned inflammatory biomarkers, the respective mean values being 7.38 and 8.11 μmol/l, 1.12 and 1.61 mg/l, and 4.23 and 4.74×109/l.

Conclusions: Resting HR is associated with a microinflammatory response in apparently healthy men and in those with atherothrombotic risk factors. Sympathetic activation might be a common factor explaining such an association. If confirmed in additional studies, this association might be a relevant target for therapeutic manipulations.

  • ACE, angiotensin converting enzyme
  • ARB, angiotensin II receptor blockers
  • BMI, body mass index
  • HDL, high density lipoprotein
  • HR, heart rate
  • hs-CRP, high-sensitivity C-reactive protein
  • LDL, low density lipoprotein
  • TAMCIS, Tel Aviv Medical Center Inflammation Survey
  • WBCC, white blood cell count

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Footnotes

  • Published Online First 18 January 2007

  • OR and IS should both be considered first authors.

  • Competing interests: None declared.

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