Background: Atrial fibrillation (AF) and atrial flutter (AFL) are common cardiac conduction disorders affecting many people. Recent studies on sporadic cases of AF/AFL showed a significant association of the single nucleotide polymorphism rs2200733T with the disease, suggesting a genetic factor in the development of the disease.
Objectives: To determine the association of rs2200733 with AF/AFL derived from an Italian population sample.
Subjects: 78 patients with AF/AFL and 348 controls took part in the study.
Design: Genetic case–control study.
Results: The results indicate that there is a positive, significant association between the rs2200733 T allele and patients with AF/AFL of Italian origin (allelic p<0.001 with OR = 2.17).
Conclusion: These results derived from a sample of the Italian population agree with previously reported findings from an Icelandic study, which also found that the minor allele rs2200733 was associated with AF/AFL disease.
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Competing interests: None for this manuscript. However, for purposes of complete transparency, AAP has a non-funding affiliation with Elixir Pharmaceuticals.
Funding: Italian Ministry of Health (1% funds), Italian Ministry of Research and University (FIRB). VN and RR are supported by a fellowship of the Doctorate School of Molecular Medicine, University of Milan, Italy.
Ethics approval: Ethics approval was obtained.